Literature DB >> 29409784

Bacterial type III secretion system as a protein delivery tool for a broad range of biomedical applications.

Fang Bai1, Zhenpeng Li1, Akihiro Umezawa2, Naohiro Terada3, Shouguang Jin4.   

Abstract

A protein delivery tool based on bacterial type III secretion system (T3SS) has been broadly applied in biomedical researches. In this review, we summarize various applications of the T3SS-mediate protein delivery which enables translocation of proteins directly into mammalian cells without protein purification. Some of the remarkable advancements include delivery of antigens for therapeutic vaccines, nucleases for genome editing, transcription factors for cellular reprogramming and stem cells differentiation, and signaling molecules for post-translational proteomics studies. With continued improvement of the T3SS-mediated protein delivery tools, even wider application of the technology is anticipated.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cellular; Genome editing; Protein delivery; Reprogramming; Stem cell differentiation; Type III secretion system; Vaccine

Mesh：

Substances：

Year:  2018        PMID： 29409784      PMCID： PMC7145356          DOI： 10.1016/j.biotechadv.2018.01.016

Source DB:  PubMed          Journal:  Biotechnol Adv        ISSN： 0734-9750            Impact factor:   14.227


  128 in total

1.  Translocation of ExsE into Chinese hamster ovary cells is required for transcriptional induction of the Pseudomonas aeruginosa type III secretion system.

Authors:  Mark L Urbanowski; Evan D Brutinel; Timothy L Yahr
Journal:  Infect Immun       Date:  2007-07-16       Impact factor: 3.441

2.  Structure of a pathogenic type 3 secretion system in action.

Authors:  Julia Radics; Lisa Königsmaier; Thomas C Marlovits
Journal:  Nat Struct Mol Biol       Date:  2013-12-08       Impact factor: 15.369

3.  Efficient Gene Editing in Pluripotent Stem Cells by Bacterial Injection of Transcription Activator-Like Effector Nuclease Proteins.

Authors:  Jingyue Jia; Fang Bai; Yongxin Jin; Katherine E Santostefano; Un-Hwan Ha; Donghai Wu; Weihui Wu; Naohiro Terada; Shouguang Jin
Journal:  Stem Cells Transl Med       Date:  2015-06-10       Impact factor: 6.940

4.  Protection against murine listeriosis by oral vaccination with recombinant Salmonella expressing hybrid Yersinia type III proteins.

Authors:  H Rüssmann; E I Igwe; J Sauer; W D Hardt; A Bubert; G Geginat
Journal:  J Immunol       Date:  2001-07-01       Impact factor: 5.422

5.  A TAL-Based Reporter Assay for Monitoring Type III-Dependent Protein Translocation in Xanthomonas.

Authors:  Sabine Drehkopf; Jens Hausner; Michael Jordan; Felix Scheibner; Ulla Bonas; Daniela Büttner
Journal:  Methods Mol Biol       Date:  2017

6.  Electromechanical integration of cardiomyocytes derived from human embryonic stem cells.

Authors:  Izhak Kehat; Leonid Khimovich; Oren Caspi; Amira Gepstein; Rona Shofti; Gil Arbel; Irit Huber; Jonathan Satin; Joseph Itskovitz-Eldor; Lior Gepstein
Journal:  Nat Biotechnol       Date:  2004-09-26       Impact factor: 54.908

7.  Pseudomonas aeruginosa injects NDK into host cells through a type III secretion system.

Authors:  Dennis Neeld; Yongxin Jin; Candace Bichsel; Jinghua Jia; Jianhui Guo; Fang Bai; Weihui Wu; Un-Hwan Ha; Naohiro Terada; Shouguang Jin
Journal:  Microbiology (Reading)       Date:  2014-04-03       Impact factor: 2.777

8.  Efficiency of conditionally attenuated Salmonella enterica serovar Typhimurium in bacterium-mediated tumor therapy.

Authors:  Michael Frahm; Sebastian Felgner; Dino Kocijancic; Manfred Rohde; Michael Hensel; Roy Curtiss; Marc Erhardt; Siegfried Weiss
Journal:  MBio       Date:  2015-04-14       Impact factor: 7.867

Review 9.  PAMPs and DAMPs: signal 0s that spur autophagy and immunity.

Authors:  Daolin Tang; Rui Kang; Carolyn B Coyne; Herbert J Zeh; Michael T Lotze
Journal:  Immunol Rev       Date:  2012-09       Impact factor: 12.988

10.  piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells.

Authors:  Knut Woltjen; Iacovos P Michael; Paria Mohseni; Ridham Desai; Maria Mileikovsky; Riikka Hämäläinen; Rebecca Cowling; Wei Wang; Pentao Liu; Marina Gertsenstein; Keisuke Kaji; Hoon-Ki Sung; Andras Nagy
Journal:  Nature       Date:  2009-03-01       Impact factor: 49.962
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  15 in total

1.  Heterologous Assembly of the Type VI Secretion System Empowers Laboratory Escherichia coli with Antimicrobial and Cell Penetration Capabilities.

Authors:  Yang Cui; Tong-Tong Pei; Xiaoye Liang; Hao Li; Hao-Yu Zheng; Tao Dong
Journal:  Appl Environ Microbiol       Date:  2022-09-26       Impact factor: 5.005

Review 2.  Pseudomonas aeruginosa in Cancer Therapy: Current Knowledge, Challenges and Future Perspectives.

Authors:  Zheng Pang; Meng-Di Gu; Tong Tang
Journal:  Front Oncol       Date:  2022-04-28       Impact factor: 5.738

3.  Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol.

Authors:  Antoine Chabloz; Jonas V Schaefer; Ivona Kozieradzki; Shane J F Cronin; Daniel Strebinger; Francesca Macaluso; Jiri Wald; Terence H Rabbitts; Andreas Plückthun; Thomas C Marlovits; Josef M Penninger
Journal:  Commun Biol       Date:  2020-07-03

4.  Visualization of translocons in Yersinia type III protein secretion machines during host cell infection.

Authors:  Theresa Nauth; Franziska Huschka; Michaela Schweizer; Jens B Bosse; Andreas Diepold; Antonio Virgilio Failla; Anika Steffen; Theresia E B Stradal; Manuel Wolters; Martin Aepfelbacher
Journal:  PLoS Pathog       Date:  2018-12-26       Impact factor: 6.823

5.  LITESEC-T3SS - Light-controlled protein delivery into eukaryotic cells with high spatial and temporal resolution.

Authors:  Florian Lindner; Bailey Milne-Davies; Katja Langenfeld; Thorsten Stiewe; Andreas Diepold
Journal:  Nat Commun       Date:  2020-05-13       Impact factor: 14.919

6.  Analysis of HrpG regulons and HrpG-interacting proteins by ChIP-seq and affinity proteomics in Xanthomonas campestris.

Authors:  Hong-Yu Zhang; Jin-Wei Wei; Wei Qian; Chao-Ying Deng
Journal:  Mol Plant Pathol       Date:  2020-01-08       Impact factor: 5.663

7.  Burkholderia gladioli CGB10: A Novel Strain Biocontrolling the Sugarcane Smut Disease.

Authors:  Guobing Cui; Kai Yin; Nuoqiao Lin; Meiling Liang; Chengwei Huang; Changqing Chang; Pinggen Xi; Yi Zhen Deng
Journal:  Microorganisms       Date:  2020-12-07

8.  N-terminal signal peptides facilitate the engineering of PVC complex as a potent protein delivery system.

Authors:  Feng Jiang; Jiawei Shen; Jiaxuan Cheng; Xia Wang; Jianguo Yang; Ningning Li; Ning Gao; Qi Jin
Journal:  Sci Adv       Date:  2022-04-29       Impact factor: 14.957

Review 9.  Bacterial type III secretion systems: a complex device for the delivery of bacterial effector proteins into eukaryotic host cells.

Authors:  Samuel Wagner; Iwan Grin; Silke Malmsheimer; Nidhi Singh; Claudia E Torres-Vargas; Sibel Westerhausen
Journal:  FEMS Microbiol Lett       Date:  2018-10-01       Impact factor: 2.742

10.  Engineered Type Six Secretion Systems Deliver Active Exogenous Effectors and Cre Recombinase.

Authors:  Steven J Hersch; Linh Lam; Tao G Dong
Journal:  mBio       Date:  2021-07-20       Impact factor: 7.867
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