Literature DB >> 29409712

Squeezing Flux Out of Fat.

Alba Gonzalez-Franquesa1, Mary-Elizabeth Patti2.   

Abstract

Merging transcriptomics or metabolomics data remains insufficient for metabolic flux estimation. Ramirez et al. integrate a genome-scale metabolic model with extracellular flux data to predict and validate metabolic differences between white and brown adipose tissue. This method allows both metabolic phenotyping and the identification of potential therapeutic targets for obesity.
Copyright © 2018 Elsevier Ltd. All rights reserved.

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Year:  2018        PMID： 29409712      PMCID： PMC6366633          DOI： 10.1016/j.tem.2018.01.005

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  11 in total

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Authors:  Markus W Covert; Eric M Knight; Jennifer L Reed; Markus J Herrgard; Bernhard O Palsson
Journal:  Nature       Date:  2004-05-06       Impact factor: 49.962

Review 2.  Beneficial effects of L-arginine on reducing obesity: potential mechanisms and important implications for human health.

Authors:  Jason R McKnight; M Carey Satterfield; Wenjuan S Jobgen; Stephen B Smith; Thomas E Spencer; Cynthia J Meininger; Catherine J McNeal; Guoyao Wu
Journal:  Amino Acids       Date:  2010-05-01       Impact factor: 3.520

Review 3.  Branched-chain amino acids in metabolic signalling and insulin resistance.

Authors:  Christopher J Lynch; Sean H Adams
Journal:  Nat Rev Endocrinol       Date:  2014-10-07       Impact factor: 43.330

4.  What is flux balance analysis?

Authors:  Jeffrey D Orth; Ines Thiele; Bernhard Ø Palsson
Journal:  Nat Biotechnol       Date:  2010-03       Impact factor: 54.908

5.  Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.

Authors:  Christian Frezza; Liang Zheng; Ori Folger; Kartik N Rajagopalan; Elaine D MacKenzie; Livnat Jerby; Massimo Micaroni; Barbara Chaneton; Julie Adam; Ann Hedley; Gabriela Kalna; Ian P M Tomlinson; Patrick J Pollard; Dave G Watson; Ralph J Deberardinis; Tomer Shlomi; Eytan Ruppin; Eyal Gottlieb
Journal:  Nature       Date:  2011-08-17       Impact factor: 49.962

6.  Candidate metabolic network states in human mitochondria. Impact of diabetes, ischemia, and diet.

Authors:  Ines Thiele; Nathan D Price; Thuy D Vo; Bernhard Ø Palsson
Journal:  J Biol Chem       Date:  2004-11-30       Impact factor: 5.157

7.  A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.

Authors:  Christopher B Newgard; Jie An; James R Bain; Michael J Muehlbauer; Robert D Stevens; Lillian F Lien; Andrea M Haqq; Svati H Shah; Michelle Arlotto; Cris A Slentz; James Rochon; Dianne Gallup; Olga Ilkayeva; Brett R Wenner; William S Yancy; Howard Eisenson; Gerald Musante; Richard S Surwit; David S Millington; Mark D Butler; Laura P Svetkey
Journal:  Cell Metab       Date:  2009-04       Impact factor: 27.287

8.  Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes.

Authors:  Christopher Nogiec; Alison Burkart; Jonathan M Dreyfuss; Carles Lerin; Simon Kasif; Mary-Elizabeth Patti
Journal:  Mol Metab       Date:  2015-01-02       Impact factor: 7.422

9.  Reconstruction and validation of a genome-scale metabolic model for the filamentous fungus Neurospora crassa using FARM.

Authors:  Jonathan M Dreyfuss; Jeremy D Zucker; Heather M Hood; Linda R Ocasio; Matthew S Sachs; James E Galagan
Journal:  PLoS Comput Biol       Date:  2013-07-18       Impact factor: 4.475

10.  Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism.

Authors:  Carles Lerin; Allison B Goldfine; Tanner Boes; Manway Liu; Simon Kasif; Jonathan M Dreyfuss; Ana Luisa De Sousa-Coelho; Grace Daher; Irini Manoli; Justin R Sysol; Elvira Isganaitis; Niels Jessen; Laurie J Goodyear; Kirk Beebe; Walt Gall; Charles P Venditti; Mary-Elizabeth Patti
Journal:  Mol Metab       Date:  2016-08-06       Impact factor: 7.422
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