Literature DB >> 2940958

[Metabolism of monocarbons and trisomy 21: sensitivity to methotrexate].

J Lejeune, M O Rethoré, M C de Blois, C Maunoury-Burolla, M Mir, L Nicolle, F Borowy, E Borghi, D Recan.   

Abstract

A diminution of the mitotic index, proportionnal to the square of the dose of methotrexate, was observed in lymphocyte cultures. Six trisomy 21 patients were twice as sensitive as six controls. This highly significant result confirms the hypothesis of a disturbance of monocarbons' metabolism in trisomy 21.

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Year:  1986        PMID： 2940958

Source DB:  PubMed          Journal:  Ann Genet        ISSN： 0003-3995


  7 in total

1.  Homocysteine and the methotrexate toxicity in trisomy 21.

Authors:  J Lejeune; M Peeters; M O Rethore; M C de Blois
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

2.  Homocysteine and related genetic polymorphisms in Down's syndrome IQ.

Authors:  J-L Guéant; G Anello; P Bosco; R-M Guéant-Rodríguez; A Romano; C Barone; P Gérard; C Romano
Journal:  J Neurol Neurosurg Psychiatry       Date:  2005-05       Impact factor: 10.154

3.  Amino acid profile in Down's syndrome.

Authors:  H J Heggarty; R Ball; M Smith; M J Henderson
Journal:  Arch Dis Child       Date:  1996-04       Impact factor: 3.791

4.  Down syndrome and leukemia: unusual clinical aspects and unexpected methotrexate sensitivity.

Authors:  M Peeters; A Poon
Journal:  Eur J Pediatr       Date:  1987-07       Impact factor: 3.183

Review 5.  The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders.

Authors:  T Bottiglieri; K Hyland; E H Reynolds
Journal:  Drugs       Date:  1994-08       Impact factor: 9.546

6.  The transcriptome profile of human trisomy 21 blood cells.

Authors:  Francesca Antonaros; Rossella Zenatelli; Giulia Guerri; Matteo Bertelli; Chiara Locatelli; Beatrice Vione; Francesca Catapano; Alice Gori; Lorenza Vitale; Maria Chiara Pelleri; Giuseppe Ramacieri; Guido Cocchi; Pierluigi Strippoli; Maria Caracausi; Allison Piovesan
Journal:  Hum Genomics       Date:  2021-05-01       Impact factor: 4.639

Review 7.  Methylenetetrahydrofolate reductase A1298C genetic variant& risk of schizophrenia: A meta-analysis.

Authors:  Vandana Rai; Upendra Yadav; Pradeep Kumar; Sushil K Yadav; Sanjay Gupta
Journal:  Indian J Med Res       Date:  2017-04       Impact factor: 2.375
  7 in total

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