Riccardo D'Ambrosi1, Camilla Maccario2, Chiara Ursino3, Nicola Serra4, Federico Giuseppe Usuelli5. 1. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy; Istituto Ortopedico Galeazzi, U.O. C.A.S.C.O. - Piede e Caviglia, Milan, Italy. Electronic address: riccardo.dambrosi@hotmail.it. 2. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy; Istituto Ortopedico Galeazzi, U.O. C.A.S.C.O. - Piede e Caviglia, Milan, Italy. 3. Università Vita-Salute San Raffaele, Milan, Italy. 4. Seconda Università degli Studi di Napoli, Naples, Italy. 5. Istituto Ortopedico Galeazzi, U.O. C.A.S.C.O. - Piede e Caviglia, Milan, Italy.
Abstract
BACKGROUND: To assess the functional and radiological outcomes after arthroscopic talus autologous matrix-induced chondrogenesis (AT-AMIC®) in 2 groups: patients with and without bone marrow edema (BME). METHODS: Thirty-seven patients of which 24 without edema (GNE) and 13 with edema (GE) were evaluated. All patients were treated with AT-AMIC® repair for symptomatic osteochondral talar lesion. Clinical and radiological parameters were evaluated with VAS score for pain, AOFAS and SF-12 at T0 (preoperatively), T1 (6 months), T2 (12 months), T3 (24 months) and MRI and CT-scan at T0, T1, T2 and T3. RESULTS: No patients were lost to the final follow-up. In both groups we found a significant difference for clinical and radiological parameters with ANOVA for repeated measures through four time points (p<0.001). In GNE, AOFAS improved significantly at each follow-up (p<0.05); while CT and MRI showed a significant reduction in lesion size between T1 and T2 and T2 and T3 (p<0.05). In GE, AOFAS improved significantly between T0 and T1 and T2 and T3 (p<0.05); lesion size, measured with CT, decreased between T1 and T2 (p<0.05), while with MRI the lesion showed a reduction at each follow-up (p<0.05). Lesion size was significantly higher both in MRI and CT in GE compared to GNE (p<0.05). In GNE no patients presented edema at T3, while in GE only 23.08% of the patients presented edema at T3. CONCLUSIONS: The study revealed that osteochondral lesions of the talus were characterized by bigger size both in MRI and CT in patients with edema. We conclude that AT-AMIC® can be considered a safe and reliable procedure that allows effective healing, regardless of edema and more than half of patients did not present edema six months after surgery.
BACKGROUND: To assess the functional and radiological outcomes after arthroscopic talus autologous matrix-induced chondrogenesis (AT-AMIC®) in 2 groups: patients with and without bone marrow edema (BME). METHODS: Thirty-seven patients of which 24 without edema (GNE) and 13 with edema (GE) were evaluated. All patients were treated with AT-AMIC® repair for symptomatic osteochondral talar lesion. Clinical and radiological parameters were evaluated with VAS score for pain, AOFAS and SF-12 at T0 (preoperatively), T1 (6 months), T2 (12 months), T3 (24 months) and MRI and CT-scan at T0, T1, T2 and T3. RESULTS: No patients were lost to the final follow-up. In both groups we found a significant difference for clinical and radiological parameters with ANOVA for repeated measures through four time points (p<0.001). In GNE, AOFAS improved significantly at each follow-up (p<0.05); while CT and MRI showed a significant reduction in lesion size between T1 and T2 and T2 and T3 (p<0.05). In GE, AOFAS improved significantly between T0 and T1 and T2 and T3 (p<0.05); lesion size, measured with CT, decreased between T1 and T2 (p<0.05), while with MRI the lesion showed a reduction at each follow-up (p<0.05). Lesion size was significantly higher both in MRI and CT in GE compared to GNE (p<0.05). In GNE no patients presented edema at T3, while in GE only 23.08% of the patients presented edema at T3. CONCLUSIONS: The study revealed that osteochondral lesions of the talus were characterized by bigger size both in MRI and CT in patients with edema. We conclude that AT-AMIC® can be considered a safe and reliable procedure that allows effective healing, regardless of edema and more than half of patients did not present edema six months after surgery.
Authors: Giovanni Foti; Matteo Catania; Simone Caia; Luigi Romano; Alberto Beltramello; Claudio Zorzi; Giovanni Carbognin Journal: Radiol Med Date: 2019-07-04 Impact factor: 3.469
Authors: Pascal R van Diepen; Jari Dahmen; J Nienke Altink; Sjoerd A S Stufkens; Gino M M J Kerkhoffs Journal: Cartilage Date: 2020-09-10 Impact factor: 4.634