Wei Huang1,2, Lu Wang3, Jianping Li2,4, Mochuan Liu3, Hongbing Xu1,2, Shengcong Liu1,2, Jie Chen1,2, Yi Zhang1,2, Masako Morishita5, Robert L Bard6, Jack R Harkema7, Sanjay Rajagopalan8, Robert D Brook6. 1. Department of Occupational and Environmental Health, Peking University School of Public Health and First Hospital Peking University, Beijing, China. 2. Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China. 3. School of Public Health, University of Michigan, Ann Arbor, Michigan, USA. 4. Division of Cardiology, Peking University First Hospital, Beijing, China. 5. Department of Family Medicine, College of Human Medicine, Michigan State University, East Lansing, Michigan, USA. 6. Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA. 7. Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA. 8. Division of Cardiovascular Medicine, Case Western Reserve Medical School, Cleveland, Ohio, USA.
Abstract
BACKGROUND: Fine particulate matter (PM2.5) air pollution is a leading cause of global cardiovascular mortality. A key mechanism may be PM2.5-induced blood pressure (BP) elevations. Whether consistent prohypertensive responses persist across the breadth of worldwide pollution concentrations has never been investigated. METHODS: We evaluated the hemodynamic impact of short-term exposures to ambient PM2.5 in harmonized studies of healthy normotensive adults (4 BP measurements per participant) living in both a highly polluted (Beijing) and clean (Michigan) location. RESULTS: Prior 7-day outdoor-ambient and 24-hour personal-level PM2.5 concentration averages were much higher in Beijing (86.7 ± 52.1 and 52.4 ± 79.2 µg/m3) compared to Michigan (9.1 ± 1.8 and 12.2 ± 17.0 µg/m3). In Beijing (n = 73), increased outdoor-ambient exposures (per 10 µg/m3) during the prior 1-7 days were associated with significant elevations in diastolic BP (0.15-0.17 mm Hg). In overweight adults (body mass index ≥25 kg/m2), significant increases in both systolic (0.34-0.44 mm Hg) and diastolic (0.22-0.66 mm Hg) BP levels were observed. Prior 24-hour personal-level exposures also significantly increased BP (0.41/0.61 mm Hg) in overweight participants. Conversely, low PM2.5 concentrations in Michigan (n = 50), on average within Air Quality Guidelines, were not associated with BP elevations. CONCLUSIONS: Our findings demonstrate that short-term exposures to ambient PM2.5 in a highly polluted environment can promote elevations in BP even among healthy adults. The fact that no adverse hemodynamic responses were observed in a clean location supports the key public health importance of international efforts to improve air quality as part of the global battle against hypertension.
BACKGROUND: Fine particulate matter (PM2.5) air pollution is a leading cause of global cardiovascular mortality. A key mechanism may be PM2.5-induced blood pressure (BP) elevations. Whether consistent prohypertensive responses persist across the breadth of worldwide pollution concentrations has never been investigated. METHODS: We evaluated the hemodynamic impact of short-term exposures to ambient PM2.5 in harmonized studies of healthy normotensive adults (4 BP measurements per participant) living in both a highly polluted (Beijing) and clean (Michigan) location. RESULTS: Prior 7-day outdoor-ambient and 24-hour personal-level PM2.5 concentration averages were much higher in Beijing (86.7 ± 52.1 and 52.4 ± 79.2 µg/m3) compared to Michigan (9.1 ± 1.8 and 12.2 ± 17.0 µg/m3). In Beijing (n = 73), increased outdoor-ambient exposures (per 10 µg/m3) during the prior 1-7 days were associated with significant elevations in diastolic BP (0.15-0.17 mm Hg). In overweight adults (body mass index ≥25 kg/m2), significant increases in both systolic (0.34-0.44 mm Hg) and diastolic (0.22-0.66 mm Hg) BP levels were observed. Prior 24-hour personal-level exposures also significantly increased BP (0.41/0.61 mm Hg) in overweight participants. Conversely, low PM2.5 concentrations in Michigan (n = 50), on average within Air Quality Guidelines, were not associated with BP elevations. CONCLUSIONS: Our findings demonstrate that short-term exposures to ambient PM2.5 in a highly polluted environment can promote elevations in BP even among healthy adults. The fact that no adverse hemodynamic responses were observed in a clean location supports the key public health importance of international efforts to improve air quality as part of the global battle against hypertension.
Authors: Robert D Brook; Robert L Bard; Richard T Burnett; Hwashin H Shin; Alan Vette; Carry Croghan; Michael Phillips; Charles Rodes; Jonathan Thornburg; Ron Williams Journal: Occup Environ Med Date: 2010-10-08 Impact factor: 4.402
Authors: Robert D Brook; Bruce Urch; J Timothy Dvonch; Robert L Bard; Mary Speck; Gerald Keeler; Masako Morishita; Frank J Marsik; Ali S Kamal; Niko Kaciroti; Jack Harkema; Paul Corey; Frances Silverman; Diane R Gold; Greg Wellenius; Murray A Mittleman; Sanjay Rajagopalan; Jeffrey R Brook Journal: Hypertension Date: 2009-07-20 Impact factor: 10.190
Authors: Ranjini M Krishnan; Sara D Adar; Adam A Szpiro; Neal W Jorgensen; Victor C Van Hee; R Graham Barr; Marie S O'Neill; David M Herrington; Joseph F Polak; Joel D Kaufman Journal: J Am Coll Cardiol Date: 2012-10-24 Impact factor: 24.094
Authors: Paolo Giorgini; Paolo Di Giosia; Davide Grassi; Melvyn Rubenfire; Robert D Brook; Claudio Ferri Journal: Curr Pharm Des Date: 2016 Impact factor: 3.116
Authors: Dan L Crouse; Paul A Peters; Aaron van Donkelaar; Mark S Goldberg; Paul J Villeneuve; Orly Brion; Saeeda Khan; Dominic Odwa Atari; Michael Jerrett; C Arden Pope; Michael Brauer; Jeffrey R Brook; Randall V Martin; David Stieb; Richard T Burnett Journal: Environ Health Perspect Date: 2012-02-07 Impact factor: 9.031
Authors: Aaron J Cohen; Michael Brauer; Richard Burnett; H Ross Anderson; Joseph Frostad; Kara Estep; Kalpana Balakrishnan; Bert Brunekreef; Lalit Dandona; Rakhi Dandona; Valery Feigin; Greg Freedman; Bryan Hubbell; Amelia Jobling; Haidong Kan; Luke Knibbs; Yang Liu; Randall Martin; Lidia Morawska; C Arden Pope; Hwashin Shin; Kurt Straif; Gavin Shaddick; Matthew Thomas; Rita van Dingenen; Aaron van Donkelaar; Theo Vos; Christopher J L Murray; Mohammad H Forouzanfar Journal: Lancet Date: 2017-04-10 Impact factor: 79.321
Authors: Masako Morishita; Lu Wang; Kelly Speth; Nina Zhou; Robert L Bard; Fengyao Li; Jeffrey R Brook; Sanjay Rajagopalan; Robert D Brook Journal: Am J Hypertens Date: 2019-10-16 Impact factor: 2.689
Authors: Ashlyn C Harmon; Alexandra Noël; Balamurugan Subramanian; Zakia Perveen; Merilyn H Jennings; Yi-Fan Chen; Arthur L Penn; Kelsey Legendre; Daniel B Paulsen; Kurt J Varner; Tammy R Dugas Journal: Am J Physiol Heart Circ Physiol Date: 2021-08-20 Impact factor: 5.125
Authors: Enembe O Okokon; Tarja Yli-Tuomi; Taina Siponen; Pekka Tiittanen; Anu W Turunen; Leena Kangas; Ari Karppinen; Jaakko Kukkonen; Timo Lanki Journal: Int J Environ Res Public Health Date: 2021-01-29 Impact factor: 3.390
Authors: Emily A Clementi; Angela Talusan; Sandhya Vaidyanathan; Arul Veerappan; Mena Mikhail; Dean Ostrofsky; George Crowley; James S Kim; Sophia Kwon; Anna Nolan Journal: Toxics Date: 2019-01-30
Authors: Hanns Moshammer; Julian Panholzer; Lisa Ulbing; Emanuel Udvarhelyi; Barbara Ebenbauer; Stefanie Peter Journal: Int J Environ Res Public Health Date: 2019-03-04 Impact factor: 3.390