Fast Spatial Resolution Analysis of Quadratic Penalized Least-Squares Image Reconstruction With Separate Real and Imaginary Roughness Penalty: Application to fMRI.

Penalized least-squares iterative image reconstruction algorithms used for spatial resolution-limited imaging, such as functional magnetic resonance imaging (fMRI), commonly use a quadratic roughness penalty to regularize the reconstructed images. When used for complex-valued images, the conventional roughness penalty regularizes the real and imaginary parts equally. However, these imaging methods sometimes benefit from separate penalties for each part. The spatial smoothness from the roughness penalty on the reconstructed image is dictated by the regularization parameter(s). One method to set the parameter to a desired smoothness level is to evaluate the full width at half maximum of the reconstruction method's local impulse response. Previous work has shown that when using the conventional quadratic roughness penalty, one can approximate the local impulse response using an FFT-based calculation. However, that acceleration method cannot be applied directly for separate real and imaginary regularization. This paper proposes a fast and stable calculation for this case that also uses FFT-based calculations to approximate the local impulse responses of the real and imaginary parts. This approach is demonstrated with a quadratic image reconstruction of fMRI data that uses separate roughness penalties for the real and imaginary parts.