Wenzhen Li1, Wenyu Ruan2, Ying Peng3, Dongming Wang4. 1. Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. 2. Department of Clinical Medicine, Xi'an Medical University, Xi'an, Shanxi, China. 3. Department of Emergency, Wuhan Centers for Diseases Prevention and Control, Wuhan, Hubei 430015, China. 4. Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Wuhan Prevention and Treatment Center for Occupational Diseases, Wuhan, Hubei 430015, China. Electronic address: wangdongming2008@126.com.
Abstract
BACKGROUND: Increasing studies have focused on the relationship between soy intake and type 2 diabetes mellitus risk, but the results are inconsistent. We conduct a meta-analysis to evaluate the relationship. METHODS: The databases of PubMed, Web of Science and Embase were searched up to Dec 2016. A random-effect model was used to pool the results of included studies. RESULTS: Eight studies with 19 reports met the inclusion criteria. A significant inverse association was shown between soy intake and type 2 diabetes mellitus risk with an overall RR of 0.77 (95% CI = 0.66-0.91) with high heterogeneity. Besides, there was an obvious relationship between soy protein and isoflavones intake and risk of T2DM with the summary RR was 0.88 (95% CI = 0.80-0.97) with no heterogeneity. In the subgroup analysis, a statistically significant protective effect of soy consumption was observed in women (RR = 0.65; 95% CI = 0.49-0.87), cross-sectional studies (RR = 0.45; 95% CI = 0.30-0.67), and Asian populations (RR = 0.73; 95% CI = 0.61-0.88). CONCLUSIONS: Soy products and soy constituents (soy protein and soy isoflavones) may be associated with a lower risk of type 2 diabetes mellitus. Future studies should focus on the dose-response effect and the mechanism.
BACKGROUND: Increasing studies have focused on the relationship between soy intake and type 2 diabetes mellitus risk, but the results are inconsistent. We conduct a meta-analysis to evaluate the relationship. METHODS: The databases of PubMed, Web of Science and Embase were searched up to Dec 2016. A random-effect model was used to pool the results of included studies. RESULTS: Eight studies with 19 reports met the inclusion criteria. A significant inverse association was shown between soy intake and type 2 diabetes mellitus risk with an overall RR of 0.77 (95% CI = 0.66-0.91) with high heterogeneity. Besides, there was an obvious relationship between soy protein and isoflavones intake and risk of T2DM with the summary RR was 0.88 (95% CI = 0.80-0.97) with no heterogeneity. In the subgroup analysis, a statistically significant protective effect of soy consumption was observed in women (RR = 0.65; 95% CI = 0.49-0.87), cross-sectional studies (RR = 0.45; 95% CI = 0.30-0.67), and Asian populations (RR = 0.73; 95% CI = 0.61-0.88). CONCLUSIONS: Soy products and soy constituents (soy protein and soy isoflavones) may be associated with a lower risk of type 2 diabetes mellitus. Future studies should focus on the dose-response effect and the mechanism.
Authors: Adriana Aparecida Ferraz Carbonel; Rafael André da Silva; Luiz Philipe de Souza Ferreira; Renata Ramos Vieira; Ricardo Dos Santos Simões; Gisela Rodrigues da Silva Sasso; Manuel de Jesus Simões; José Maria Soares Junior; Patrícia Daniele Azevedo Lima; Fernanda Teixeira Borges Journal: Nutrients Date: 2022-06-21 Impact factor: 6.706