| Literature DB >> 29405974 |
Narsireddy Amreddy1, Anish Babu1, Ranganayaki Muralidharan1, Janani Panneerselvam1, Akhil Srivastava1, Rebaz Ahmed2, Meghna Mehta1, Anupama Munshi1, Rajagopal Ramesh3.
Abstract
Effective and safe delivery of anticancer agents is among the major challenges in cancer therapy. The majority of anticancer agents are toxic to normal cells, have poor bioavailability, and lack in vivo stability. Recent advancements in nanotechnology provide safe and efficient drug delivery systems for successful delivery of anticancer agents via nanoparticles. The physicochemical and functional properties of the nanoparticle vary for each of these anticancer agents, including chemotherapeutics, nucleic acid-based therapeutics, small molecule inhibitors, and photodynamic agents. The characteristics of the anticancer agents influence the design and development of nanoparticle carriers. This review focuses on strategies of nanoparticle-based drug delivery for various anticancer agents. Recent advancements in the field are also highlighted, with suitable examples from our own research efforts and from the literature.Entities:
Keywords: Chemotherapeutics; Drug delivery; Exosomes; Gene therapy; Nanoparticle; Tumor targeting
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Year: 2017 PMID： 29405974 PMCID： PMC6550462 DOI： 10.1016/bs.acr.2017.11.003
Source DB: PubMed Journal: Adv Cancer Res ISSN： 0065-230X Impact factor: 6.242