Literature DB >> 29404398

Gene gating at nuclear pores prevents the formation of R loops.

Hélène Gaillard1, Francisco García-Benítez1, Andrés Aguilera1.   

Abstract

Transcription is an important source of genetic variability. A large amount of transcription-associated genome variation arises from the unscheduled formation of R loops. We have recently found that physical proximity of chromatin to nuclear pores prevents the formation of pathological R loops during transcription. Our study opens new perspectives to understand genome stability as a function of nuclear location.

Keywords:  R loop; genome instability; genome organization; nuclear pores; transcription

Year:  2017        PMID： 29404398      PMCID： PMC5791852          DOI： 10.1080/23723556.2017.1405140

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Cotranscriptional recruitment to the mRNA export receptor Mex67p contributes to nuclear pore anchoring of activated genes.

Authors:  Guennaelle Dieppois; Nahid Iglesias; Françoise Stutz
Journal:  Mol Cell Biol       Date:  2006-09-05       Impact factor: 4.272

2.  The nuclear pore regulates GAL1 gene transcription by controlling the localization of the SUMO protease Ulp1.

Authors:  Lorane Texari; Guennaëlle Dieppois; Patrizia Vinciguerra; Mariana Pardo Contreras; Anna Groner; Audrey Letourneau; Françoise Stutz
Journal:  Mol Cell       Date:  2013-09-26       Impact factor: 17.970

3.  Gene loops function to maintain transcriptional memory through interaction with the nuclear pore complex.

Authors:  Sue Mei Tan-Wong; Hashanthi D Wijayatilake; Nick J Proudfoot
Journal:  Genes Dev       Date:  2009-11-15       Impact factor: 11.361

4.  Gene gating: a hypothesis.

Authors:  G Blobel
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

5.  Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion.

Authors:  Sandra Krull; Julia Dörries; Björn Boysen; Sonja Reidenbach; Lars Magnius; Helene Norder; Johan Thyberg; Volker C Cordes
Journal:  EMBO J       Date:  2010-04-20       Impact factor: 11.598

6.  Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability.

Authors:  Francisco García-Benítez; Hélène Gaillard; Andrés Aguilera
Journal:  Proc Natl Acad Sci U S A       Date:  2017-09-25       Impact factor: 11.205

Review 7.  R loops: new modulators of genome dynamics and function.

Authors:  José M Santos-Pereira; Andrés Aguilera
Journal:  Nat Rev Genet       Date:  2015-09-15       Impact factor: 53.242

8.  The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores.

Authors:  Rodrigo Bermejo; Thelma Capra; Rachel Jossen; Arianna Colosio; Camilla Frattini; Walter Carotenuto; Andrea Cocito; Ylli Doksani; Hannah Klein; Belén Gómez-González; Andrés Aguilera; Yuki Katou; Katsuhiko Shirahige; Marco Foiani
Journal:  Cell       Date:  2011-07-22       Impact factor: 41.582

9.  The core spliceosome as target and effector of non-canonical ATM signalling.

Authors:  Maria Tresini; Daniël O Warmerdam; Petros Kolovos; Loes Snijder; Mischa G Vrouwe; Jeroen A A Demmers; Wilfred F J van IJcken; Frank G Grosveld; René H Medema; Jan H J Hoeijmakers; Leon H F Mullenders; Wim Vermeulen; Jurgen A Marteijn
Journal:  Nature       Date:  2015-06-24       Impact factor: 49.962

10.  Nucleoporin-mediated regulation of cell identity genes.

Authors:  Arkaitz Ibarra; Chris Benner; Swati Tyagi; Jonah Cool; Martin W Hetzer
Journal:  Genes Dev       Date:  2016-11-02       Impact factor: 11.361
  10 in total
  1 in total

Review 1.  R-loops as Janus-faced modulators of DNA repair.

Authors:  Aline Marnef; Gaëlle Legube
Journal:  Nat Cell Biol       Date:  2021-04-09       Impact factor: 28.824
  1 in total

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