Literature DB >> 33837288

R-loops as Janus-faced modulators of DNA repair.

Aline Marnef1, Gaëlle Legube2.   

Abstract

R-loops are non-B DNA structures with intriguing dual consequences for gene expression and genome stability. In addition to their recognized roles in triggering DNA double-strand breaks (DSBs), R-loops have recently been demonstrated to accumulate in cis to DSBs, especially those induced in transcriptionally active loci. In this Review, we discuss whether R-loops actively participate in DSB repair or are detrimental by-products that must be removed to avoid genome instability.

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Year:  2021        PMID： 33837288     DOI： 10.1038/s41556-021-00663-4

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  144 in total

1.  The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops.

Authors:  Rosa Luna; Ana G Rondón; Carmen Pérez-Calero; Irene Salas-Armenteros; Andrés Aguilera
Journal:  Cold Spring Harb Symp Quant Biol       Date:  2020-06-03

2.  R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters.

Authors:  Paul A Ginno; Paul L Lott; Holly C Christensen; Ian Korf; Frédéric Chédin
Journal:  Mol Cell       Date:  2012-03-01       Impact factor: 17.970

Review 3.  R-Loops as Cellular Regulators and Genomic Threats.

Authors:  Madzia P Crossley; Michael Bocek; Karlene A Cimprich
Journal:  Mol Cell       Date:  2019-02-07       Impact factor: 17.970

Review 4.  RNA: a double-edged sword in genome maintenance.

Authors:  Dali Zong; Philipp Oberdoerffer; Pedro J Batista; André Nussenzweig
Journal:  Nat Rev Genet       Date:  2020-08-06       Impact factor: 53.242

5.  m6A RNA modification as a new player in R-loop regulation.

Authors:  Aline Marnef; Gaëlle Legube
Journal:  Nat Genet       Date:  2020-01       Impact factor: 38.330

Review 6.  R Loops: From Physiological to Pathological Roles.

Authors:  Tatiana García-Muse; Andrés Aguilera
Journal:  Cell       Date:  2019-10-10       Impact factor: 41.582

Review 7.  Emerging roles for R-loop structures in the management of topological stress.

Authors:  Frederic Chedin; Craig J Benham
Journal:  J Biol Chem       Date:  2020-02-27       Impact factor: 5.157

8.  Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals.

Authors:  Lionel A Sanz; Stella R Hartono; Yoong Wearn Lim; Sandra Steyaert; Aparna Rajpurkar; Paul A Ginno; Xiaoqin Xu; Frédéric Chédin
Journal:  Mol Cell       Date:  2016-06-30       Impact factor: 17.970

9.  Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites.

Authors:  Alexy Promonet; Ismaël Padioleau; Yaqun Liu; Lionel Sanz; Anna Biernacka; Anne-Lyne Schmitz; Magdalena Skrzypczak; Amélie Sarrazin; Clément Mettling; Maga Rowicka; Krzysztof Ginalski; Frédéric Chedin; Chun-Long Chen; Yea-Lih Lin; Philippe Pasero
Journal:  Nat Commun       Date:  2020-08-07       Impact factor: 14.919

10.  RNase H1 directs origin-specific initiation of DNA replication in human mitochondria.

Authors:  Viktor Posse; Ali Al-Behadili; Jay P Uhler; Anders R Clausen; Aurelio Reyes; Massimo Zeviani; Maria Falkenberg; Claes M Gustafsson
Journal:  PLoS Genet       Date:  2019-01-03       Impact factor: 5.917
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  26 in total

1.  Activation of homologous recombination in G1 preserves centromeric integrity.

Authors:  Duygu Yilmaz; Audrey Furst; Karen Meaburn; Aleksandra Lezaja; Yanlin Wen; Matthias Altmeyer; Bernardo Reina-San-Martin; Evi Soutoglou
Journal:  Nature       Date:  2021-12-01       Impact factor: 49.962

Review 2.  Transcriptional regulation and chromatin dynamics at DNA double-strand breaks.

Authors:  Sunwoo Min; Jae-Hoon Ji; Yungyeong Heo; Hyeseong Cho
Journal:  Exp Mol Med       Date:  2022-10-13       Impact factor: 12.153

3.  RNase H1 Hybrid-Binding Domain-Based Tools for Cellular Biology Studies of DNA-RNA Hybrids in Mammalian Cells.

Authors:  Sónia Silva; Cristina Guillén-Mendoza; Andrés Aguilera
Journal:  Methods Mol Biol       Date:  2022

4.  DNA-RNA Hybrids at Telomeres in Budding Yeast.

Authors:  Carolin B Wagner; Brian Luke
Journal:  Methods Mol Biol       Date:  2022

Review 5.  R-loop Mediated DNA Damage and Impaired DNA Repair in Spinal Muscular Atrophy.

Authors:  Juliana Cuartas; Laxman Gangwani
Journal:  Front Cell Neurosci       Date:  2022-06-16       Impact factor: 6.147

Review 6.  Sources, resolution and physiological relevance of R-loops and RNA-DNA hybrids.

Authors:  Eva Petermann; Li Lan; Lee Zou
Journal:  Nat Rev Mol Cell Biol       Date:  2022-04-22       Impact factor: 113.915

Review 7.  Walking a tightrope: The complex balancing act of R-loops in genome stability.

Authors:  Joshua R Brickner; Jada L Garzon; Karlene A Cimprich
Journal:  Mol Cell       Date:  2022-05-03       Impact factor: 19.328

Review 8.  The Ultimate (Mis)match: When DNA Meets RNA.

Authors:  Benoit Palancade; Rodney Rothstein
Journal:  Cells       Date:  2021-06-08       Impact factor: 7.666

Review 9.  RNA Polymerase III, Ageing and Longevity.

Authors:  Yavuz Kulaberoglu; Yasir Malik; Gillian Borland; Colin Selman; Nazif Alic; Jennifer M A Tullet
Journal:  Front Genet       Date:  2021-07-06       Impact factor: 4.599

10.  Hypoxia-induced SETX links replication stress with the unfolded protein response.

Authors:  Shaliny Ramachandran; Tiffany S Ma; Jon Griffin; Natalie Ng; Iosifina P Foskolou; Ming-Shih Hwang; Pedro Victori; Wei-Chen Cheng; Francesca M Buffa; Katarzyna B Leszczynska; Sherif F El-Khamisy; Natalia Gromak; Ester M Hammond
Journal:  Nat Commun       Date:  2021-06-17       Impact factor: 14.919
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