Yong-Ping Lu1,2,3, Christoph Reichetzeder1, Cornelia Prehn4, Karoline von Websky1, Torsten Slowinski2, You-Peng Chen5, Liang-Hong Yin3, Burkhard Kleuser1, Xue-Song Yang6, Jerzy Adamski4,7,8, Berthold Hocher1,6,9. 1. Institute of Nutritional Science, University of Potsdam, Potsdam-Rehbrücke, Germany. 2. Department of Nephrology, Charité - Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany. 3. Department of Nephrology, the first Affiliated Hospital of Jinan University, Guangzhou, China. 4. Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. 5. Department of Infectious Diseases, the first Affiliated Hospital of Jinan University, Guangzhou, China. 6. Department of Embryology, Basic Medical College, Jinan University Guangzhou, Guangzhou, China. 7. Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany. 8. German Center for Diabetes Research (DZD), München-Neuherberg, Germany. 9. Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha, China.
Abstract
BACKGROUND/AIMS: Gestational diabetes (GDM) might be associated with alterations in the metabolomic profile of affected mothers and their offspring. Until now, there is a paucity of studies that investigated both, the maternal and the fetal serum metabolome in the setting of GDM. Mounting evidence suggests that the fetus is not just passively affected by gestational disease but might play an active role in it. Metabolomic studies performed in maternal blood and fetal cord blood could help to better discern distinct fetal from maternal disease interactions. METHODS: At the time of birth, serum samples from mothers and newborns (cord blood samples) were collected and screened for 163 metabolites utilizing tandem mass spectrometry. The cohort consisted of 412 mother/child pairs, including 31 cases of maternal GDM. RESULTS: An initial non-adjusted analysis showed that eight metabolites in the maternal blood and 54 metabolites in the cord blood were associated with GDM. After Benjamini-Hochberg (BH) procedure and adjustment for confounding factors for GDM, fetal phosphatidylcholine acyl-alkyl C 32: 1 and proline still showed an independent association with GDM. CONCLUSIONS: This study found metabolites in cord blood which were associated with GDM, even after adjustment for established risk factors of GDM. To the best of our knowledge, this is the first study demonstrating an independent association between fetal serum metabolites and maternal GDM. Our findings might suggest a potential effect of the fetal metabolome on maternal GDM.
BACKGROUND/AIMS: Gestational diabetes (GDM) might be associated with alterations in the metabolomic profile of affected mothers and their offspring. Until now, there is a paucity of studies that investigated both, the maternal and the fetal serum metabolome in the setting of GDM. Mounting evidence suggests that the fetus is not just passively affected by gestational disease but might play an active role in it. Metabolomic studies performed in maternal blood and fetal cord blood could help to better discern distinct fetal from maternal disease interactions. METHODS: At the time of birth, serum samples from mothers and newborns (cord blood samples) were collected and screened for 163 metabolites utilizing tandem mass spectrometry. The cohort consisted of 412 mother/child pairs, including 31 cases of maternal GDM. RESULTS: An initial non-adjusted analysis showed that eight metabolites in the maternal blood and 54 metabolites in the cord blood were associated with GDM. After Benjamini-Hochberg (BH) procedure and adjustment for confounding factors for GDM, fetal phosphatidylcholineacyl-alkyl C 32: 1 and proline still showed an independent association with GDM. CONCLUSIONS: This study found metabolites in cord blood which were associated with GDM, even after adjustment for established risk factors of GDM. To the best of our knowledge, this is the first study demonstrating an independent association between fetal serum metabolites and maternal GDM. Our findings might suggest a potential effect of the fetal metabolome on maternal GDM.
Authors: Ionela Mihaela Vladu; Diana Clenciu; Adina Mitrea; Anca Amzolini; Simona Elena Micu; Anda Elena Crisan; Ion Cristian Efrem; Maria Fortofoiu; Mircea Catalin Fortofoiu; Adrian Mita; Anca Barau Alhija; Adina Dorina Glodeanu; Maria Mota Journal: Metabolites Date: 2022-04-22
Authors: Simone Renner; Ana Sofia Martins; Elisabeth Streckel; Christina Braun-Reichhart; Mattias Backman; Cornelia Prehn; Nikolai Klymiuk; Andrea Bähr; Andreas Blutke; Christina Landbrecht-Schessl; Annegret Wünsch; Barbara Kessler; Mayuko Kurome; Arne Hinrichs; Sietse-Jan Koopmans; Stefan Krebs; Elisabeth Kemter; Birgit Rathkolb; Hiroshi Nagashima; Helmut Blum; Mathias Ritzmann; Rüdiger Wanke; Bernhard Aigner; Jerzy Adamski; Martin Hrabě de Angelis; Eckhard Wolf Journal: Dis Model Mech Date: 2019-08-12 Impact factor: 5.758
Authors: Ana Sofía Herrera-Van Oostdam; Mariana Salgado-Bustamante; Victoria Lima-Rogel; Juan José Oropeza-Valdez; Jesús Adrián López; Iván Daniel Román Rodríguez; Juan Carlos Toro-Ortiz; David Alejandro Herrera-Van Oostdam; Yamilé López-Hernández; Joel Monárrez-Espino Journal: Metabolites Date: 2021-10-22