Sabrina G Fabi1,2,3, Lisa Zaleski-Larsen1,2,3, Joanna Bolton1,2,3, Rahul C Mehta1,2,3, Elizabeth T Makino1,2,3. 1. Dr. Fabi is with Cosmetic Laser Dermatology and is a volunteer Assistant Clinical Professor at the University of California, San Diego in San Diego, California. 2. Drs. Zaleski-Larsen and Bolton are with Cosmetic Laser Dermatology in San Diego, California. 3. Dr. Mehta and Ms. Makino are with SkinMedica, Inc., an Allergan Company in Irvine, California.
Abstract
BACKGROUND: Neuromodulator injection procedures are an effective treatment for moderate-to-severe facial wrinkles, but do not address the superficial fine lines and wrinkles caused by age-related loss of intrinsic hyaluronic acid levels in the epidermis. OBJECTIVE: In this study, the authors assess overall facial skin quality and patient satisfaction when combining topical treatment with the a topical cosmetic serum (HA5) and applying to the entire face following a pre-elected neuromodulator injection treatment to the lateral canthal areas. METHODS AND MATERIALS: Twenty female subjects aged 36 to 63 years with moderate-to-severe under-the-eye fine lines and/or wrinkles enrolled in the study. HA5 was applied the entire face at baseline immediately post-injection and twice daily for eight weeks. Clinical assessments were conducted at baseline; 15 minutes post-procedure; and at Weeks 2, 4, and 8. RESULTS: Statistically significant improvements were observed immediately post-procedure and after eight weeks, along with high patient satisfaction. CONCLUSION: The combination of topical serum and injectable procedure provided a rapid onset of improvements in fine lines/wrinkles appearance and skin texture and long-term overall improvements in areas not treated by the injection. These results support how this novel combination can provide physicians with a comprehensive approach to optimize patient outcomes.
BACKGROUND: Neuromodulator injection procedures are an effective treatment for moderate-to-severe facial wrinkles, but do not address the superficial fine lines and wrinkles caused by age-related loss of intrinsic hyaluronic acid levels in the epidermis. OBJECTIVE: In this study, the authors assess overall facial skin quality and patient satisfaction when combining topical treatment with the a topical cosmetic serum (HA5) and applying to the entire face following a pre-elected neuromodulator injection treatment to the lateral canthal areas. METHODS AND MATERIALS: Twenty female subjects aged 36 to 63 years with moderate-to-severe under-the-eye fine lines and/or wrinkles enrolled in the study. HA5 was applied the entire face at baseline immediately post-injection and twice daily for eight weeks. Clinical assessments were conducted at baseline; 15 minutes post-procedure; and at Weeks 2, 4, and 8. RESULTS: Statistically significant improvements were observed immediately post-procedure and after eight weeks, along with high patient satisfaction. CONCLUSION: The combination of topical serum and injectable procedure provided a rapid onset of improvements in fine lines/wrinkles appearance and skin texture and long-term overall improvements in areas not treated by the injection. These results support how this novel combination can provide physicians with a comprehensive approach to optimize patient outcomes.
Authors: Fan Liu; Merel A Hamer; Joris Deelen; Japal S Lall; Leonie Jacobs; Diana van Heemst; Peter G Murray; Andreas Wollstein; Anton J M de Craen; Hae-Won Uh; Changqing Zeng; Albert Hofman; André G Uitterlinden; Jeanine J Houwing-Duistermaat; Luba M Pardo; Marian Beekman; P Eline Slagboom; Tamar Nijsten; Manfred Kayser; David A Gunn Journal: Curr Biol Date: 2016-04-28 Impact factor: 10.834
Authors: Alastair Carruthers; Suzanne Bruce; Sue Ellen Cox; Michael A C Kane; Elisabeth Lee; Conor J Gallagher Journal: Aesthet Surg J Date: 2016-03-15 Impact factor: 4.283
Authors: Vic A Narurkar; Sabrina G Fabi; Vivian W Bucay; Ruth Tedaldi; Jeanine B Downie; Joshua A Zeichner; Kimberly Butterwick; Amy Taub; Kuniko Kadoya; Elizabeth T Makino; Rahul C Mehta; Virginia L Vega Journal: J Drugs Dermatol Date: 2016-01 Impact factor: 2.114