L van Zutphen1, S Maier2,3, N Siep1, G A Jacob4, O Tüscher5, L Tebartz van Elst3, A Zeeck2, A Arntz1,6, M-F O'Connor7, H Stamm2, M Hudek2, Andreas Joos8,9. 1. Department of Clinical Psychological Science, Maastricht University, Maastricht, The Netherlands. 2. Department of Psychosomatic Medicine and Psychotherapy, Medical Center, University of Freiburg Faculty of Medicine, University of Freiburg, Hauptstraße 8, 79104, Freiburg, Germany. 3. Department of Psychiatry and Psychotherapy, Medical Center, University of Freiburg Faculty of Medicine, University of Freiburg, Freiburg, Germany. 4. Institute of Psychology, University of Freiburg, Freiburg, Germany. 5. Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Germany. 6. Department of Clinical Psychology, University of Amsterdam, Amsterdam, The Netherlands. 7. Department of Psychology, University of Arizona, Tucson, USA. 8. Department of Psychosomatic Medicine and Psychotherapy, Medical Center, University of Freiburg Faculty of Medicine, University of Freiburg, Hauptstraße 8, 79104, Freiburg, Germany. andreas.joos@uniklinik-freiburg.de. 9. Department of Psychotherapeutic Neurology, Kliniken Schmieder Gailingen, Gailingen, Germany. andreas.joos@uniklinik-freiburg.de.
Abstract
BACKGROUND: Intimacy is a key psychological problem in anorexia nervosa (AN). Empirical evidence, including neurobiological underpinnings, is however, scarce. OBJECTIVE: In this study, we evaluated various emotional stimuli including intimate stimuli experienced in patients with AN and non-patients, as well as their cerebral response. METHODS: Functional magnetic resonance imaging was conducted using stimuli with positive, neutral, negative and intimate content. Participants (14 AN patients and 14 non-patients) alternated between passive viewing and explicit emotion regulation. RESULTS: Intimate stimuli were experienced less positively in AN patients compared to non-patients. AN patients showed decreased cerebral responses in superior parietal cortices in response to positive and intimate stimuli. Intimate stimuli led to stronger activation of the orbitofrontal cortex, and lower activation of the bilateral precuneus in AN patients. Orbitofrontal responses decreased in AN patients during explicit emotion regulation. CONCLUSIONS: These results show that intimate stimuli are of particular importance in AN patients, who show experiential differences compared to non-patients and altered activation of orbitofrontal and parietal brain structures. This supports that AN patients have difficulties with intimacy, attachment, self-referential processing and body perception. LEVEL OF EVIDENCE: Level III, case-control study.
BACKGROUND: Intimacy is a key psychological problem in anorexia nervosa (AN). Empirical evidence, including neurobiological underpinnings, is however, scarce. OBJECTIVE: In this study, we evaluated various emotional stimuli including intimate stimuli experienced in patients with AN and non-patients, as well as their cerebral response. METHODS: Functional magnetic resonance imaging was conducted using stimuli with positive, neutral, negative and intimate content. Participants (14 AN patients and 14 non-patients) alternated between passive viewing and explicit emotion regulation. RESULTS: Intimate stimuli were experienced less positively in AN patients compared to non-patients. AN patients showed decreased cerebral responses in superior parietal cortices in response to positive and intimate stimuli. Intimate stimuli led to stronger activation of the orbitofrontal cortex, and lower activation of the bilateral precuneus in AN patients. Orbitofrontal responses decreased in AN patients during explicit emotion regulation. CONCLUSIONS: These results show that intimate stimuli are of particular importance in AN patients, who show experiential differences compared to non-patients and altered activation of orbitofrontal and parietal brain structures. This supports that AN patients have difficulties with intimacy, attachment, self-referential processing and body perception. LEVEL OF EVIDENCE: Level III, case-control study.
Authors: Silja Vocks; Martin Busch; Dietrich Grönemeyer; Dietmar Schulte; Stephan Herpertz; Boris Suchan Journal: J Psychiatry Neurosci Date: 2010-05 Impact factor: 6.186
Authors: Andreas A B Joos; Emmanuelle Cabrillac; Armin Hartmann; Michael Wirsching; Almut Zeeck Journal: Int J Eat Disord Date: 2009-05 Impact factor: 4.861