Je-Ming Hu1,2,3, Cheng-Jung Shen4, Yu-Ching Chou4, Chi-Feng Hung5,6, Yu-Feng Tian7, San-Lin You5,6, Chao-Yang Chen1,3, Chih-Hsiung Hsu2,3, Cheng-Wen Hsiao1, Chun-Yu Lin8, Chien-An Sun9,10. 1. Division of Colorectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan. 2. Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei City, Taiwan. 3. School of Medicine, National Defense Medical Center, Taipei City, Taiwan. 4. School of Public Health, National Defense Medical Center, Taipei City, Taiwan. 5. Department of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan. 6. Big Data Research Center, College of Medicine, Fu Jen Catholic University, No. 510, Zhongzheng Road, Xinzhuang District, New Taipei City, 24205, Taiwan, Republic of China. 7. Division of General Surgery, Department of Surgery, Chi-Mei Hospital, Tainan, Taiwan. 8. Division of Colorectal Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan. 9. Big Data Research Center, College of Medicine, Fu Jen Catholic University, No. 510, Zhongzheng Road, Xinzhuang District, New Taipei City, 24205, Taiwan, Republic of China. 040866@mail.fju.edu.tw. 10. Department of Public Health, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan. 040866@mail.fju.edu.tw.
Abstract
BACKGROUND: Periodontal disease (PD) and colorectal cancer (CRC) were associated with chronic inflammation. This retrospective cohort study examined the association between PD severity and CRC in a large-scale, population-based Chinese cohort. METHODS: A total of approximately 106,487 individuals with newly diagnosed PD and 106,487 age-matched and sex-matched patients without PD from 2000 to 2002 were identified from Taiwan's National Health Insurance Research Database (NHIRD). RESULTS: The Kaplan-Meier analysis revealed that the cumulative incidence of CRC was significantly higher in patients with PD than in those without PD (log-rank test, P < 0.001). After adjustment for age, sex, and comorbidities, patients with PD were associated with a significantly higher risk of CRC compared with those without PD (adjusted HR = 1.64, 95% CI = 1.50-1.80). Further, the risk of CRC appeared to increase with increasing frequency of PD medical visits [adjusted HR (95% CI) was 1.78 (1.58-2.02) and 1.53 (1.35-1.74) for annual visits > 10 and < 4, respectively]. CONCLUSION: Based on our study, PD severity was associated with an increase in the risk of CRC. Further mechanistic research is needed.
BACKGROUND:Periodontal disease (PD) and colorectal cancer (CRC) were associated with chronic inflammation. This retrospective cohort study examined the association between PD severity and CRC in a large-scale, population-based Chinese cohort. METHODS: A total of approximately 106,487 individuals with newly diagnosed PD and 106,487 age-matched and sex-matched patients without PD from 2000 to 2002 were identified from Taiwan's National Health Insurance Research Database (NHIRD). RESULTS: The Kaplan-Meier analysis revealed that the cumulative incidence of CRC was significantly higher in patients with PD than in those without PD (log-rank test, P < 0.001). After adjustment for age, sex, and comorbidities, patients with PD were associated with a significantly higher risk of CRC compared with those without PD (adjusted HR = 1.64, 95% CI = 1.50-1.80). Further, the risk of CRC appeared to increase with increasing frequency of PD medical visits [adjusted HR (95% CI) was 1.78 (1.58-2.02) and 1.53 (1.35-1.74) for annual visits > 10 and < 4, respectively]. CONCLUSION: Based on our study, PD severity was associated with an increase in the risk of CRC. Further mechanistic research is needed.
Entities:
Keywords:
Colorectal cancer (CRC); National Health Insurance Research Database (NHIRD); Periodontal disease (PD); Retrospective cohort study
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