Literature DB >> 29391917

Injection of Botulinum Toxin for Preventing Salivary Gland Toxicity after PSMA Radioligand Therapy: an Empirical Proof of a Promising Concept.

Richard P Baum1, Thomas Langbein1, Aviral Singh1, Mostafa Shahinfar1, Christiane Schuchardt1, Gerd Fabian Volk2, Harshad Kulkarni1.   

Abstract

The dose-limiting salivary gland toxicity of 225Ac-labelled PSMA for treatment of metastatic, castration-resistant prostate cancer remains unresolved. Suppressing the metabolism of the gland by intraparenchymal injections of botulinum toxin appears to be a promising method to reduce off-target uptake. A 68Ga-PSMA PET/CT scan performed 45 days after injection of 80 units of botulinum toxin A into the right parotid gland in a 63-year-old patient showed a decrease in the SUVmean in the right parotid gland of up to 64% as compared with baseline. This approach could be a significant breakthrough for radioprotection of the salivary glands during PSMA radioligand therapy.

Entities:  

Keywords:  Botulinum toxin; PSMA radioligands; Positron emission tomography; Prostate cancer; Salivary glands; Xerostomia

Year:  2018        PMID： 29391917      PMCID： PMC5777965          DOI： 10.1007/s13139-017-0508-3

Source DB:  PubMed          Journal:  Nucl Med Mol Imaging        ISSN： 1869-3474


  5 in total

1.  Botulinum toxin assessment, intervention and aftercare for paediatric and adult drooling: international consensus statement.

Authors:  D Reddihough; C E Erasmus; H Johnson; G M W McKellar; P H Jongerius
Journal:  Eur J Neurol       Date:  2010-08       Impact factor: 6.089

2.  Targeted α-Therapy of Metastatic Castration-Resistant Prostate Cancer with 225Ac-PSMA-617: Dosimetry Estimate and Empiric Dose Finding.

Authors:  Clemens Kratochwil; Frank Bruchertseifer; Hendrik Rathke; Marcus Bronzel; Christos Apostolidis; Wilko Weichert; Uwe Haberkorn; Frederik L Giesel; Alfred Morgenstern
Journal:  J Nucl Med       Date:  2017-04-13       Impact factor: 10.057

Review 3.  Salivary gland botulinum toxin injections for drooling in children with cerebral palsy and neurodevelopmental disability: a systematic review.

Authors:  Kate Rodwell; Priya Edwards; Robert S Ware; Roslyn Boyd
Journal:  Dev Med Child Neurol       Date:  2012-09-05       Impact factor: 5.449

4.  Safety and Efficacy of Botulinum Toxin to Preserve Gland Function after Radiotherapy in Patients with Head and Neck Cancer: A Prospective, Randomized, Placebo-Controlled, Double-Blinded Phase I Clinical Trial.

Authors:  Afshin Teymoortash; Andreas Pfestroff; Andrea Wittig; Nora Franke; Stephan Hoch; Susanne Harnisch; Carmen Schade-Brittinger; Helmut Hoeffken; Rita Engenhart-Cabillic; Markus Brugger; Konstantin Strauch
Journal:  PLoS One       Date:  2016-03-18       Impact factor: 3.240

5.  Targeted alpha therapy of mCRPC: Dosimetry estimate of 213Bismuth-PSMA-617.

Authors:  Clemens Kratochwil; Karl Schmidt; Ali Afshar-Oromieh; Frank Bruchertseifer; Hendrik Rathke; Alfred Morgenstern; Uwe Haberkorn; Frederik L Giesel
Journal:  Eur J Nucl Med Mol Imaging       Date:  2017-09-11       Impact factor: 9.236
  5 in total
  28 in total

1.  Comparison of Prostate-Specific Membrane Antigen Expression Levels in Human Salivary Glands to Non-Human Primates and Rodents.

Authors:  Jyoti Roy; Blake M Warner; Falguni Basuli; Xiang Zhang; Karen Wong; Thomas Pranzatelli; Anita T Ton; John A Chiorini; Peter L Choyke; Frank I Lin; Elaine M Jagoda
Journal:  Cancer Biother Radiopharm       Date:  2020-02-19       Impact factor: 3.099

2.  Value proposition of PSMA-targeted α-particle radioligand therapy in metastatic prostate cancer.

Authors:  Hossein Jadvar
Journal:  Eur J Nucl Med Mol Imaging       Date:  2018-10-11       Impact factor: 9.236

3.  Initial clinical experience performing sialendoscopy for salivary gland protection in patients undergoing 225Ac-PSMA-617 RLT.

Authors:  Hendrik Rathke; Clemens Kratochwil; Ralph Hohenberger; Frederik Lars Giesel; Frank Bruchertseifer; Paul Flechsig; Alfred Morgenstern; Matti Hein; Peter Plinkert; Uwe Haberkorn; Olcay Cem Bulut
Journal:  Eur J Nucl Med Mol Imaging       Date:  2018-08-27       Impact factor: 9.236

4.  Sublingual Atropine Administration as a Tool to Decrease Salivary Glands' PSMA-Ligand Uptake: A Preclinical Proof of Concept Study Using [68Ga]Ga-PSMA-11.

Authors:  Vincent Nail; Béatrice Louis; Anaïs Moyon; Adrien Chabert; Laure Balasse; Samantha Fernandez; Guillaume Hache; Philippe Garrigue; David Taïeb; Benjamin Guillet
Journal:  Pharmaceutics       Date:  2022-06-16       Impact factor: 6.525

Review 5.  Theranostics of prostate cancer: from molecular imaging to precision molecular radiotherapy targeting the prostate specific membrane antigen.

Authors:  Harshad R Kulkarni; Aviral Singh; Thomas Langbein; Christiane Schuchardt; Dirk Mueller; Jingjing Zhang; Coline Lehmann; Richard P Baum
Journal:  Br J Radiol       Date:  2018-06-01       Impact factor: 3.039

6.  The Impact of Monosodium Glutamate on 68Ga-PSMA-11 Biodistribution in Men with Prostate Cancer: A Prospective Randomized, Controlled Imaging Study.

Authors:  Wesley R Armstrong; Andrei Gafita; Shaojun Zhu; Pan Thin; Kathleen Nguyen; Rejah Alano; Stephanie Lira; Kiara Booker; Linda Gardner; Tristan Grogan; David Elashoff; Martin Allen-Auerbach; Magnus Dahlbom; Johannes Czernin; Jeremie Calais
Journal:  J Nucl Med       Date:  2021-01-28       Impact factor: 11.082

7.  Monosodium Glutamate Reduces 68Ga-PSMA-11 Uptake in Salivary Glands and Kidneys in a Preclinical Prostate Cancer Model.

Authors:  Etienne Rousseau; Joseph Lau; Hsiou-Ting Kuo; Zhengxing Zhang; Helen Merkens; Navjit Hundal-Jabal; Nadine Colpo; Kuo-Shyan Lin; François Bénard
Journal:  J Nucl Med       Date:  2018-08-10       Impact factor: 10.057

Review 8.  Targeted Radionuclide Therapy: New Advances for Improvement of Patient Management and Response.

Authors:  Javian Malcolm; Nadia Falzone; Boon Q Lee; Katherine A Vallis
Journal:  Cancers (Basel)       Date:  2019-02-25       Impact factor: 6.575

9.  Competitive blocking of salivary gland [18F]DCFPyL uptake via localized, retrograde ductal injection of non-radioactive DCFPyL: a preclinical study.

Authors:  Jyoti Roy; Blake M Warner; Falguni Basuli; Xiang Zhang; Changyu Zheng; Corrine Goldsmith; Tim Phelps; Karen Wong; Anita T Ton; Rick Pieschl; Margaret E White; Rolf Swenson; John A Chiorini; Peter L Choyke; Frank I Lin
Journal:  EJNMMI Res       Date:  2021-07-21       Impact factor: 3.138

10.  Potential Applications of 68Ga-PSMA-11 PET/CT in the Evaluation of Salivary Gland Uptake Function: Preliminary Observations and Comparison with 99mTcO4 - Salivary Gland Scintigraphy.

Authors:  Yanhong Zhao; Yuxiao Xia; Huipan Liu; Zi Wang; Yue Chen; Wei Zhang
Journal:  Contrast Media Mol Imaging       Date:  2020-01-11       Impact factor: 3.161
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