PURPOSE OF REVIEW: To review publications relating to apolipoprotein L1 (APOL1) renal risk variants published 2017. RECENT FINDINGS: The study of APOL1 variants continues to be highly active; 24 articles published in 2017 were selected to highlight. These include clinical studies of kidney disease, kidney transplantation, hypertension, cardiovascular disease, and genetic diversity. Laboratory studies included APOL1 association with vesicle-associated membrane soluble N-ethylmaleimide-sensitive factor activating protein receptor protein and with soluble urokinase-type plasminogen activator receptor, mitochondrial dysfunction, endolysosomal dysfunction, and inflammasome activation. SUMMARY: Our understanding of the role of APOL1 genetic variants and the mechanisms for renal toxicity continues to deepen. It is not yet clear which pathways are most relevant to human disease, and so, the most relevant drug targets remain to be defined.
PURPOSE OF REVIEW: To review publications relating to apolipoprotein L1 (APOL1) renal risk variants published 2017. RECENT FINDINGS: The study of APOL1 variants continues to be highly active; 24 articles published in 2017 were selected to highlight. These include clinical studies of kidney disease, kidney transplantation, hypertension, cardiovascular disease, and genetic diversity. Laboratory studies included APOL1 association with vesicle-associated membrane soluble N-ethylmaleimide-sensitive factor activating protein receptor protein and with soluble urokinase-type plasminogen activator receptor, mitochondrial dysfunction, endolysosomal dysfunction, and inflammasome activation. SUMMARY: Our understanding of the role of APOL1 genetic variants and the mechanisms for renal toxicity continues to deepen. It is not yet clear which pathways are most relevant to human disease, and so, the most relevant drug targets remain to be defined.
Authors: Pazit Beckerman; Jing Bi-Karchin; Ae Seo Deok Park; Chengxiang Qiu; Patrick D Dummer; Irfana Soomro; Carine M Boustany-Kari; Steven S Pullen; Jeffrey H Miner; Chien-An A Hu; Tibor Rohacs; Kazunori Inoue; Shuta Ishibe; Moin A Saleem; Matthew B Palmer; Ana Maria Cuervo; Jeffrey B Kopp; Katalin Susztak Journal: Nat Med Date: 2017-02-20 Impact factor: 53.440
Authors: Girish N Nadkarni; Geneviève Galarneau; Stephen B Ellis; Rajiv Nadukuru; Jinglan Zhang; Stuart A Scott; Claudia Schurmann; Rongling Li; Laura J Rasmussen-Torvik; Abel N Kho; M Geoffrey Hayes; Jennifer A Pacheco; Teri A Manolio; Rex L Chisholm; Dan M Roden; Joshua C Denny; Eimear E Kenny; Erwin P Bottinger Journal: J Am Coll Cardiol Date: 2017-03-28 Impact factor: 24.094
Authors: Sethu M Madhavan; John F O'Toole; Martha Konieczkowski; Laura Barisoni; David B Thomas; Santhi Ganesan; Leslie A Bruggeman; Matthias Buck; John R Sedor Journal: JCI Insight Date: 2017-07-20
Authors: Teresa K Chen; Michelle M Estrella; Eric Vittinghoff; Feng Lin; Orlando M Gutierrez; Holly Kramer; Cora E Lewis; Jeffrey B Kopp; Norrina B Allen; Cheryl A Winkler; Kirsten B Bibbins-Domingo; Carmen A Peralta Journal: Kidney Int Date: 2017-05-23 Impact factor: 18.998
Authors: John W Stanifer; Francis Karia; Venance Maro; Kajiru Kilonzo; Xuejun Qin; Uptal D Patel; Elizabeth R Hauser Journal: PLoS One Date: 2017-07-21 Impact factor: 3.240
Authors: Derek K Ng; Catherine C Robertson; Robert P Woroniecki; Sophie Limou; Christopher E Gillies; Kimberly J Reidy; Cheryl A Winkler; Sangeeta Hingorani; Keisha L Gibson; Rebecca Hjorten; Christine B Sethna; Jeffrey B Kopp; Marva Moxey-Mims; Susan L Furth; Bradley A Warady; Matthias Kretzler; John R Sedor; Frederick J Kaskel; Matthew G Sampson Journal: Nephrol Dial Transplant Date: 2017-06-01 Impact factor: 5.992
Authors: Michael S Lipkowitz; Barry I Freedman; Carl D Langefeld; Mary E Comeau; Donald W Bowden; W H Linda Kao; Brad C Astor; Erwin P Bottinger; Sudha K Iyengar; Paul E Klotman; Richard G Freedman; Weijia Zhang; Rulan S Parekh; Michael J Choi; George W Nelson; Cheryl A Winkler; Jeffrey B Kopp Journal: Kidney Int Date: 2012-07-25 Impact factor: 10.612
Authors: Carlos E Duran; Alejandro Ramírez; Juan G Posada; Johanna Schweineberg; Liliana Mesa; Harry Pachajoa; Mayra Estacio; Eliana Manzi; Vanessa Aros; Lorena Díaz; Victor H Garcia Journal: Int J Nephrol Date: 2019-12-18