Literature DB >> 28143671

APOL1 Gene Kidney Risk Variants and Cardiovascular Disease: Getting to the Heart of the Matter.

Nicholas O McLean1, Todd W Robinson1, Barry I Freedman2.   

Abstract

Apolipoprotein L1 gene (APOL1) renal risk variants exhibit strong genetic associations with a spectrum of nondiabetic kidney diseases in individuals with recent African ancestry. Relationships between APOL1 kidney risk variants and cardiovascular disease (CVD) susceptibility and CVD-related death remain controversial. Some studies detected an increased risk for CVD, whereas others support protection from death and subclinical CVD and cerebrovascular disease. Because treatments for nondiabetic kidney disease may target this gene and its protein products, it remains critical to clarify the potential extrarenal effects of APOL1 kidney risk variants. This review addresses the current literature on APOL1 associations with CVD, cerebrovascular disease, and death. Potential causes of disparate results between studies are discussed.
Copyright © 2017 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  African Americans; apolipoprotein L1 (APOL1); atherosclerosis; cardiovascular disease (CVD); cerebrovascular disease; chronic kidney disease (CKD); coronary artery calcification (CAC); death; genetic risk; kidney risk variants; mortality; nonmodifiable risk factor; racial disparities; review

Mesh：

Substances：

Year:  2017        PMID： 28143671      PMCID： PMC5526726          DOI： 10.1053/j.ajkd.2016.11.020

Source DB:  PubMed          Journal:  Am J Kidney Dis        ISSN： 0272-6386            Impact factor:   11.072


  47 in total

1.  Renal insufficiency as a predictor of cardiovascular outcomes and the impact of ramipril: the HOPE randomized trial.

Authors:  J F Mann; H C Gerstein; J Pogue; J Bosch; S Yusuf
Journal:  Ann Intern Med       Date:  2001-04-17       Impact factor: 25.391

Review 2.  Are the creatinine-based equations accurate to estimate glomerular filtration rate in African American populations?

Authors:  Pierre Delanaye; Christophe Mariat; Nicolas Maillard; Jean-Marie Krzesinski; Etienne Cavalier
Journal:  Clin J Am Soc Nephrol       Date:  2011-03-24       Impact factor: 8.237

Review 3.  The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans.

Authors:  Barry I Freedman; Jeffrey B Kopp; Carl D Langefeld; Giulio Genovese; David J Friedman; George W Nelson; Cheryl A Winkler; Donald W Bowden; Martin R Pollak
Journal:  J Am Soc Nephrol       Date:  2010-08-05       Impact factor: 10.121

4.  Patterns of Kidney Function Decline Associated with APOL1 Genotypes: Results from AASK.

Authors:  Adrienne Tin; Morgan E Grams; Michelle Estrella; Michael Lipkowitz; Tom H Greene; Wen Hong Linda Kao; Liang Li; Lawrence J Appel
Journal:  Clin J Am Soc Nephrol       Date:  2016-05-26       Impact factor: 8.237

5.  Apolipoprotein L1: from obscurity to consistency to controversy.

Authors:  Michael S Lipkowitz
Journal:  Kidney Int       Date:  2015-01       Impact factor: 10.612

6.  The prevalence and severity of coronary artery calcification on coronary artery computed tomography in black and white subjects.

Authors:  Timothy C Lee; Patrick G O'Malley; Irwin Feuerstein; Allen J Taylor
Journal:  J Am Coll Cardiol       Date:  2003-01-01       Impact factor: 24.094

7.  Coronary calcium as a predictor of coronary events in four racial or ethnic groups.

Authors:  Robert Detrano; Alan D Guerci; J Jeffrey Carr; Diane E Bild; Gregory Burke; Aaron R Folsom; Kiang Liu; Steven Shea; Moyses Szklo; David A Bluemke; Daniel H O'Leary; Russell Tracy; Karol Watson; Nathan D Wong; Richard A Kronmal
Journal:  N Engl J Med       Date:  2008-03-27       Impact factor: 91.245

8.  Cardiovascular disease and subsequent kidney disease.

Authors:  Essam F Elsayed; Hocine Tighiouart; John Griffith; Tobias Kurth; Andrew S Levey; Deeb Salem; Mark J Sarnak; Daniel E Weiner
Journal:  Arch Intern Med       Date:  2007-06-11

9.  Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines.

Authors:  Lijun Ma; Gregory S Shelness; James A Snipes; Mariana Murea; Peter A Antinozzi; Dongmei Cheng; Moin A Saleem; Simon C Satchell; Bernhard Banas; Peter W Mathieson; Matthias Kretzler; Ashok K Hemal; Lawrence L Rudel; Snezana Petrovic; Allison Weckerle; Martin R Pollak; Michael D Ross; John S Parks; Barry I Freedman
Journal:  J Am Soc Nephrol       Date:  2014-07-10       Impact factor: 10.121

10.  ApoL1, a BH3-only lipid-binding protein, induces autophagic cell death.

Authors:  Siqin Zhaorigetu; Guanghua Wan; Ramesh Kaini; Zeyu Jiang; Chien-an A Hu
Journal:  Autophagy       Date:  2008-11-23       Impact factor: 16.016
View more
  15 in total

Review 1.  Hypertension in African Americans.

Authors:  Nomsa Musemwa; Crystal A Gadegbeku
Journal:  Curr Cardiol Rep       Date:  2017-10-28       Impact factor: 2.931

2.  Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1-second gene interactions.

Authors:  Carl D Langefeld; Mary E Comeau; Maggie C Y Ng; Meijian Guan; Latchezar Dimitrov; Poorva Mudgal; Mitzie H Spainhour; Bruce A Julian; Jeffrey C Edberg; Jennifer A Croker; Jasmin Divers; Pamela J Hicks; Donald W Bowden; Gary C Chan; Lijun Ma; Nicholette D Palmer; Robert P Kimberly; Barry I Freedman
Journal:  Kidney Int       Date:  2018-06-07       Impact factor: 10.612

3.  Risk of Cardiovascular Disease and Mortality in Young Adults With End-stage Renal Disease: An Analysis of the US Renal Data System.

Authors:  Zubin J Modi; Yee Lu; Nan Ji; Alissa Kapke; David T Selewski; Xue Dietrich; Kevin Abbott; Brahmajee K Nallamothu; Douglas E Schaubel; Rajiv Saran; Debbie S Gipson
Journal:  JAMA Cardiol       Date:  2019-04-01       Impact factor: 14.676

Review 4.  Genomic medicine for kidney disease.

Authors:  Emily E Groopman; Hila Milo Rasouly; Ali G Gharavi
Journal:  Nat Rev Nephrol       Date:  2018-01-08       Impact factor: 28.314

5.  APOL1 gene variants and kidney disease in whites: the cardiovascular health study.

Authors:  Erika R Drury; David J Friedman; Martin R Pollak; Joachim H Ix; Lewis H Kuller; Russell P Tracy; Kenneth J Mukamal
Journal:  Nephrol Dial Transplant       Date:  2019-12-01       Impact factor: 5.992

6.  Association of APOL1 Risk Alleles With Cardiovascular Disease in Blacks in the Million Veteran Program.

Authors:  Alexander G Bick; Elvis Akwo; Cassianne Robinson-Cohen; Kyung Lee; Julie Lynch; Themistocles L Assimes; Scott DuVall; Todd Edwards; Huaying Fang; S Matthew Freiberg; Ayush Giri; Jennifer E Huffman; Jie Huang; Leland Hull; Rachel L Kember; Derek Klarin; Jennifer S Lee; Michael Levin; Donald R Miller; Pradeep Natarajan; Danish Saleheen; Qing Shao; Yan V Sun; Hua Tang; Otis Wilson; Kyong-Mi Chang; Kelly Cho; John Concato; J Michael Gaziano; Sekar Kathiresan; Christopher J O'Donnell; Daniel J Rader; Philip S Tsao; Peter W Wilson; Adriana M Hung; Scott M Damrauer
Journal:  Circulation       Date:  2019-07-24       Impact factor: 29.690

Review 7.  Apolipoprotein L1 nephropathies: 2017 in review.

Authors:  Jeffrey B Kopp; Hila Roshanravan; Koji Okamoto
Journal:  Curr Opin Nephrol Hypertens       Date:  2018-05       Impact factor: 2.894

8.  APOL1 Sends Its REGARDS to Cardiovascular Disease.

Authors:  Joshua S Waitzman; John T Wilkins; Jennie Lin
Journal:  Circ Genom Precis Med       Date:  2018-06

9.  APOL1 Nephropathy Risk Variants and Incident Cardiovascular Disease Events in Community-Dwelling Black Adults.

Authors:  Orlando M Gutiérrez; Marguerite R Irvin; Ninad S Chaudhary; Mary Cushman; Neil A Zakai; Victor A David; Sophie Limou; Nathalie Pamir; Alex P Reiner; Rakhi P Naik; Michele M Sale; Monika M Safford; Hyacinth I Hyacinth; Suzanne E Judd; Jeffrey B Kopp; Cheryl A Winkler
Journal:  Circ Genom Precis Med       Date:  2018-06

10.  APOL1 Kidney Risk Variants and Cardiovascular Disease: An Individual Participant Data Meta-Analysis.

Authors:  Morgan E Grams; Aditya Surapaneni; Shoshana H Ballew; Lawrence J Appel; Eric Boerwinkle; L Ebony Boulware; Teresa K Chen; Josef Coresh; Mary Cushman; Jasmin Divers; Orlando M Gutiérrez; Marguerite R Irvin; Joachim H Ix; Jeffrey B Kopp; Lewis H Kuller; Carl D Langefeld; Michael S Lipkowitz; Kenneth J Mukamal; Solomon K Musani; Rakhi P Naik; Nicholas M Pajewski; Carmen A Peralta; Adrienne Tin; Christina L Wassel; James G Wilson; Cheryl A Winkler; Bessie A Young; Neil A Zakai; Barry I Freedman
Journal:  J Am Soc Nephrol       Date:  2019-08-05       Impact factor: 14.978
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.