| Literature DB >> 29386641 |
Li He1,2, Wenwu Wu1,3, Gaurav Zinta1, Lan Yang1, Dong Wang1, Renyi Liu1, Huiming Zhang1, Zhimin Zheng1, Huan Huang1, Qingzhu Zhang4,5, Jian-Kang Zhu6,7.
Abstract
Epigenetic variation has been proposed to facilitate adaptation to changing environments, but evidence that natural epialleles contribute to adaptive evolution has been lacking. Here we identify a retrotransposon, named "NMR19" (naturally occurring DNA methylation variation region 19), whose methylation and genomic location vary among Arabidopsis thaliana accessions. We classify NMR19 as NMR19-4 and NMR19-16 based on its location, and uncover NMR19-4 as an epiallele that controls leaf senescence by regulating the expression of PHEOPHYTIN PHEOPHORBIDE HYDROLASE (PPH). We find that the DNA methylation status of NMR19-4 is stably inherited and independent of genetic variation. In addition, further analysis indicates that DNA methylation of NMR19-4 correlates with local climates, implying that NMR19-4 is an environmentally associated epiallele. In summary, we discover a novel epiallele, and provide mechanistic insights into its origin and potential function in local climate adaptation.Entities:
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Year: 2018 PMID： 29386641 PMCID： PMC5792623 DOI： 10.1038/s41467-018-02839-3
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919