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Literature DB >> 29386300

In Vivo Analysis of a Gain-of-Function Mutation Confirms Unc18/Munc18's Role in Priming.

Leonardo A Parra¹.

Abstract

Entities: Gene

Mesh：

Substances：

Year: 2018 PMID： 29386300 PMCID： PMC6596262 DOI： 10.1523/JNEUROSCI.3068-17.2017

Source DB: PubMed Journal: J Neurosci ISSN： 0270-6474 Impact factor: 6.167

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20 in total

1. Single-molecule studies of SNARE complex assembly reveal parallel and antiparallel configurations.

Authors: Keith Weninger; Mark E Bowen; Steven Chu; Axel T Brunger
Journal: Proc Natl Acad Sci U S A Date: 2003-12-01 Impact factor: 11.205

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Authors: K M Misura; R H Scheller; W I Weis
Journal: Nature Date: 2000-03-23 Impact factor: 49.962

3. An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming.

Authors: J E Richmond; R M Weimer; E M Jorgensen
Journal: Nature Date: 2001-07-19 Impact factor: 49.962

4. Regulation of the UNC-18-Caenorhabditis elegans syntaxin complex by UNC-13.

Authors: T Sassa; S Harada; H Ogawa; J B Rand; I N Maruyama; R Hosono
Journal: J Neurosci Date: 1999-06-15 Impact factor: 6.167

5. The R-SNARE motif of tomosyn forms SNARE core complexes with syntaxin 1 and SNAP-25 and down-regulates exocytosis.

Authors: Kiyotaka Hatsuzawa; Thorsten Lang; Dirk Fasshauer; Dieter Bruns; Reinhard Jahn
Journal: J Biol Chem Date: 2003-06-02 Impact factor: 5.157

6. Tomosyn negatively regulates both synaptic transmitter and neuropeptide release at the C. elegans neuromuscular junction.

Authors: Elena O Gracheva; Anna O Burdina; Denis Touroutine; Martine Berthelot-Grosjean; Hetal Parekh; Janet E Richmond
Journal: J Physiol Date: 2007-07-12 Impact factor: 5.182

In Vivo Analysis of a Gain-of-Function Mutation Confirms Unc18/Munc18's Role in Priming.

1. Single-molecule studies of SNARE complex assembly reveal parallel and antiparallel configurations.

2. Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex.

3. An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming.

4. Regulation of the UNC-18-Caenorhabditis elegans syntaxin complex by UNC-13.

5. The R-SNARE motif of tomosyn forms SNARE core complexes with syntaxin 1 and SNAP-25 and down-regulates exocytosis.

6. Tomosyn negatively regulates both synaptic transmitter and neuropeptide release at the C. elegans neuromuscular junction.

7. Munc18-1 prevents the formation of ectopic SNARE complexes in living cells.

8. Binding of Munc18-1 to synaptobrevin and to the SNARE four-helix bundle.

9. Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegans.

10. Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins.