Literature DB >> 10366611

Regulation of the UNC-18-Caenorhabditis elegans syntaxin complex by UNC-13.

T Sassa1, S Harada, H Ogawa, J B Rand, I N Maruyama, R Hosono.   

Abstract

The Caenorhabditis elegans unc-13, unc-18, and unc-64 genes are required for normal synaptic transmission. The UNC-18 protein binds to the unc-64 gene product C. elegans syntaxin (Ce syntaxin). However, it is not clear how this protein complex is regulated. We show that UNC-13 transiently interacts with the UNC-18-Ce syntaxin complex, resulting in rapid displacement of UNC-18 from the complex. Genetic and biochemical evidence is presented that UNC-13 contributes to the modulation of the interaction between UNC-18 and Ce syntaxin.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10366611      PMCID： PMC6782667     

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


  41 in total

1.  A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans.

Authors:  I N Maruyama; S Brenner
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-01       Impact factor: 11.205

2.  Stages of regulated exocytosis.

Authors:  T F Martin
Journal:  Trends Cell Biol       Date:  1997-07       Impact factor: 20.808

3.  Genetic analysis of the cha-1-unc-17 gene complex in Caenorhabditis.

Authors:  J B Rand
Journal:  Genetics       Date:  1989-05       Impact factor: 4.562

4.  Distinct domains of syntaxin are required for synaptic vesicle fusion complex formation and dissociation.

Authors:  Y Kee; R C Lin; S C Hsu; R H Scheller
Journal:  Neuron       Date:  1995-05       Impact factor: 17.173

5.  Specificity and regulation of a synaptic vesicle docking complex.

Authors:  J Pevsner; S C Hsu; J E Braun; N Calakos; A E Ting; M K Bennett; R H Scheller
Journal:  Neuron       Date:  1994-08       Impact factor: 17.173

Review 6.  A molecular description of synaptic vesicle membrane trafficking.

Authors:  M K Bennett; R H Scheller
Journal:  Annu Rev Biochem       Date:  1994       Impact factor: 23.643

7.  Choline acetyltransferase-deficient mutants of the nematode Caenorhabditis elegans.

Authors:  J B Rand; R L Russell
Journal:  Genetics       Date:  1984-02       Impact factor: 4.562

8.  Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin.

Authors:  A Betz; M Okamoto; F Benseler; N Brose
Journal:  J Biol Chem       Date:  1997-01-24       Impact factor: 5.157

9.  Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process.

Authors:  Y Fujita; H Shirataki; T Sakisaka; T Asakura; T Ohya; H Kotani; S Yokoyama; H Nishioka; Y Matsuura; A Mizoguchi; R H Scheller; Y Takai
Journal:  Neuron       Date:  1998-05       Impact factor: 17.173

10.  The unc-18 gene encodes a novel protein affecting the kinetics of acetylcholine metabolism in the nematode Caenorhabditis elegans.

Authors:  R Hosono; S Hekimi; Y Kamiya; T Sassa; S Murakami; K Nishiwaki; J Miwa; A Taketo; K I Kodaira
Journal:  J Neurochem       Date:  1992-04       Impact factor: 5.372
View more
  46 in total

1.  Rules of nonallelic noncomplementation at the synapse in Caenorhabditis elegans.

Authors:  K J Yook; S R Proulx; E M Jorgensen
Journal:  Genetics       Date:  2001-05       Impact factor: 4.562

2.  Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity.

Authors:  Manuel J Muñoz; Donald L Riddle
Journal:  Genetics       Date:  2003-01       Impact factor: 4.562

3.  Expression of multiple UNC-13 proteins in the Caenorhabditis elegans nervous system.

Authors:  R E Kohn; J S Duerr; J R McManus; A Duke; T L Rakow; H Maruyama; G Moulder; I N Maruyama; R J Barstead; J B Rand
Journal:  Mol Biol Cell       Date:  2000-10       Impact factor: 4.138

4.  Identification and characterization of syntaxin 1 antisense variants in Limulus polyphemus.

Authors:  Z Cao; Y Wang; B S McAdory; M D Kemp; M T Ivy; R F Newkirk; J G Townsel
Journal:  Cell Mol Neurobiol       Date:  2006-02       Impact factor: 5.046

5.  Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions.

Authors:  Leonora F Ciufo; Jeff W Barclay; Robert D Burgoyne; Alan Morgan
Journal:  Mol Biol Cell       Date:  2004-11-24       Impact factor: 4.138

6.  A Calcium- and Diacylglycerol-Stimulated Protein Kinase C (PKC), Caenorhabditis elegans PKC-2, Links Thermal Signals to Learned Behavior by Acting in Sensory Neurons and Intestinal Cells.

Authors:  Marianne Land; Charles S Rubin
Journal:  Mol Cell Biol       Date:  2017-09-12       Impact factor: 4.272

7.  Resveratrol inhibits phorbol ester-induced membrane translocation of presynaptic Munc13-1.

Authors:  Satyabrata Pany; Anamitra Ghosh; Youngki You; Nga Nguyen; Joydip Das
Journal:  Biochim Biophys Acta Gen Subj       Date:  2017-07-13       Impact factor: 3.770

8.  Convergent, RIC-8-dependent Galpha signaling pathways in the Caenorhabditis elegans synaptic signaling network.

Authors:  Nicole K Reynolds; Michael A Schade; Kenneth G Miller
Journal:  Genetics       Date:  2004-10-16       Impact factor: 4.562

9.  Mutations that rescue the paralysis of Caenorhabditis elegans ric-8 (synembryn) mutants activate the G alpha(s) pathway and define a third major branch of the synaptic signaling network.

Authors:  Michael A Schade; Nicole K Reynolds; Claudia M Dollins; Kenneth G Miller
Journal:  Genetics       Date:  2004-10-16       Impact factor: 4.562

10.  Defects in synaptic vesicle docking in unc-18 mutants.

Authors:  Robby M Weimer; Janet E Richmond; Warren S Davis; Gayla Hadwiger; Michael L Nonet; Erik M Jorgensen
Journal:  Nat Neurosci       Date:  2003-09-14       Impact factor: 24.884
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.