Literature DB >> 2938545

Interaction of myotoxin a with the Ca2+-ATPase of skeletal muscle sarcoplasmic reticulum.

P Volpe, E Damiani, A Maurer, A T Tu.   

Abstract

Myotoxin a is a muscle-damaging toxin isolated from the venom of Crotalus viridis viridis. Its interaction with the Ca2+-ATPase of sarcoplasmic reticulum (SR) vesicles purified from rabbit skeletal muscle was investigated. Myotoxin a inhibited Ca2+ loading and stimulated Ca2+-dependent ATPase without affecting unidirectional Ca2+ efflux. Its action was dose, time, and temperature dependent. Myotoxin a partially blocked the binding of specific anti-(rabbit SR Ca2+-ATPase) antibodies. It is concluded that myotoxin a attaches to the SR Ca2+-ATPase and uncouples Ca2+ uptake from Ca2+-dependent ATP hydrolysis. Myotoxin a also prevented the formation of decavanadate-induced two-dimensional crystalline arrays of the SR Ca2+-ATPase.

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Year:  1986        PMID： 2938545     DOI： 10.1016/0003-9861(86)90452-2

Source DB:  PubMed          Journal:  Arch Biochem Biophys        ISSN： 0003-9861            Impact factor:   4.013


  4 in total

1.  Mechanism of inhibition of Ca(2+)-ATPase by myotoxin a.

Authors:  K J Baker; J M East; A G Lee
Journal:  Biochem J       Date:  1995-04-15       Impact factor: 3.857

Review 2.  Pharmacology of calcium release from sarcoplasmic reticulum.

Authors:  P Palade; C Dettbarn; D Brunder; P Stein; G Hals
Journal:  J Bioenerg Biomembr       Date:  1989-04       Impact factor: 2.945

3.  CIDNP study of the aromatic side chain interactions in myotoxin alpha.

Authors:  K A Muszkat; V Preygerzon; A T Tu
Journal:  J Protein Chem       Date:  1994-04

4.  Ca2+ release induced by myotoxin alpha, a radio-labellable probe having novel Ca2+ release properties in sarcoplasmic reticulum.

Authors:  K Furukawa; K Funayama; M Ohkura; Y Oshima; A T Tu; Y Ohizumi
Journal:  Br J Pharmacol       Date:  1994-09       Impact factor: 8.739
  4 in total

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