Sir,I read with interest the case report by Sharma et al. on the orbital dermatofibrosarcoma protuberans (DFSP) with frontal and ethmoid sinus involvement in an Indian patient.[1] The authors nicely addressed the clinical picture, diagnostic workup, and the administered modalities of treatment. It is obvious that due to low immunity, patients infected with human immunodeficiency virus (HIV) are more vulnerable to various types of tumors in comparison to the immunocompetent individuals. Among these tumors, DFSP has been reported in HIV-positive patients.[2] To the best of my knowledge, HIV infection is an important health hazard in India. Although no recent data are yet present on the exact HIV seroprevalence in India, the available data pointed out to 0.26% seroprevalence compared with a global average of 0.2%.[3] I presume that HIV infection should be critically considered in the studied patient with the aggressive DFSP and protracted clinical course. Hence, the diagnostic algorithm of blood CD4 count and viral overload estimations for HIV infection was solicited. If that diagnostic algorithm was done and it revealed underling HIV infection, the case in question could be truly considered a novel case report as HIV-associated orbital DFSP has never been reported in the literature so far.