Abbey J Hughes1, Katherine M Dunn2,3, Trisha Chaffee2. 1. Department of Physical Medicine and Rehabilitation, Division for Rehabilitation Psychology and Neuropsychology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. abbeyjhughes@jhmi.edu. 2. Department of Physical Medicine and Rehabilitation, Division for Rehabilitation Psychology and Neuropsychology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 3. Department of Psychology, Loyola University Maryland, Baltimore, MD, USA.
Abstract
PURPOSE OF REVIEW: The present review summarizes recent research on the association between sleep disturbance and cognitive dysfunction in MS. Assessment methodology, domain-specific associations between sleep disturbance and cognitive dysfunction, and implications for future research and treatment are discussed. RECENT FINDINGS: All 12 studies included in this review found significant associations between sleep disturbance and cognitive dysfunction; however, results varied considerably depending on the assessment method used and the cognitive domain assessed. Self-reported sleep disturbance generally predicted self-report but not objective measures of cognitive dysfunction. Objective sleep measures (e.g., polysomnography, actigraphy) generally predicted objective impairments in processing speed and attention; however, objective sleep disturbance was more variable in predicting performance in other cognitive domains (e.g., memory, executive function). Sleep disturbance may help predict future cognitive decline in MS. Results highlight the need to integrate sleep assessment into routine MS care. Interventions aimed treating sleep disturbance may offer promise for improving cognitive dysfunction in MS.
PURPOSE OF REVIEW: The present review summarizes recent research on the association between sleep disturbance and cognitive dysfunction in MS. Assessment methodology, domain-specific associations between sleep disturbance and cognitive dysfunction, and implications for future research and treatment are discussed. RECENT FINDINGS: All 12 studies included in this review found significant associations between sleep disturbance and cognitive dysfunction; however, results varied considerably depending on the assessment method used and the cognitive domain assessed. Self-reported sleep disturbance generally predicted self-report but not objective measures of cognitive dysfunction. Objective sleep measures (e.g., polysomnography, actigraphy) generally predicted objective impairments in processing speed and attention; however, objective sleep disturbance was more variable in predicting performance in other cognitive domains (e.g., memory, executive function). Sleep disturbance may help predict future cognitive decline in MS. Results highlight the need to integrate sleep assessment into routine MS care. Interventions aimed treating sleep disturbance may offer promise for improving cognitive dysfunction in MS.
Authors: Ralph H B Benedict; Bianca Weinstock-Guttman; Inna Fishman; Jitendra Sharma; Christopher W Tjoa; Rohit Bakshi Journal: Arch Neurol Date: 2004-02
Authors: D Cella; J-S Lai; C J Nowinski; D Victorson; A Peterman; D Miller; F Bethoux; A Heinemann; S Rubin; J E Cavazos; A T Reder; R Sufit; T Simuni; G L Holmes; A Siderowf; V Wojna; R Bode; N McKinney; T Podrabsky; K Wortman; S Choi; R Gershon; N Rothrock; C Moy Journal: Neurology Date: 2012-05-09 Impact factor: 9.910
Authors: Mohammad Mahdi Shahpouri; Majid Barekatain; Mahgol Tavakoli; Omid Mirmosayyeb; Ali Safaei; Vahid Shaygannejad Journal: Neurol Res Int Date: 2020-11-22
Authors: Aikaterini Christogianni; Richard Bibb; Scott L Davis; Ollie Jay; Michael Barnett; Nikos Evangelou; Davide Filingeri Journal: Temperature (Austin) Date: 2018-09-05
Authors: James F Sumowski; Sam Horng; Rachel Brandstadter; Stephen Krieger; Victoria M Leavitt; Ilana Katz Sand; Michelle Fabian; Sylvia Klineova; Robin Graney; Claire S Riley; Fred D Lublin; Aaron E Miller; Andrew W Varga Journal: Ann Clin Transl Neurol Date: 2021-05-05 Impact factor: 4.511