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Literature DB >> 2937584

Analysis of defective delayed-type hypersensitivity in autoimmune mice bearing lpr gene.

H Okuyama, K Yamamoto, T Matsunaga, S Kobayashi, A Tashiro.

Abstract

Many functional defects of T-cells have been found in autoimmune prone, MRL/MpJ-lpr/lpr (MRL/lpr) mice. We examined the capacity of delayed-type hypersensitivity (DTH) induction and macrophage migration inhibition factor (MIF) production. MRL/lpr and C57BL/6J-lpr/lpr (B6/lpr) mice were tested for capacity of DTH by the footpad reaction to purified protein derivative of tuberculin (PPD) and lung granuloma formation after immunization with BCG-cell wall (BCGCW). In lpr mice, the ability to induce DTH against exogeneous antigenic stimulation decreased with age. The results show that the defect of DTH in lpr mice caused by deficiency of the MIF producing capacity of proliferated T-cells rather than suppressor cell activity for MIF production.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1986 PMID： 2937584 PMCID： PMC1577344

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

17 in total

1. Genetic control of granuloma response to oil-associated BCG cell wall vaccine in mice.

Authors: K Yamamoto; M Karinuma
Journal: Microbiol Immunol Date: 1978 Impact factor: 1.955

2. Production of an antibody against guinea pig MIF. III. Biological activity of MIF recovered from immunoadsorbent column chromatography.

Authors: K Onozaki; S Haga; M Ichikawa; Y Homma; K Miura; T Hashimoto
Journal: Cell Immunol Date: 1981-06 Impact factor: 4.868

3. Duration of immunity to tuberculosis in mice vaccinated intravenously with oil-treated cell walls of Mycobacterium bovis strain BCG.

Authors: R L Anacker; W R Barclay; W Brehmer; C L Larson; E Ribi
Journal: J Immunol Date: 1967-06 Impact factor: 5.422

4. Spontaneous production of interleukin 3 by T lymphocytes from autoimmune MRL/MP-lpr/lpr mice.

Authors: R Palacios
Journal: Eur J Immunol Date: 1984-07 Impact factor: 5.532

5. Interleukin 2 deficiency is a common feature of autoimmune mice.

Authors: M J Dauphinée; S B Kipper; D Wofsy; N Talal
Journal: J Immunol Date: 1981-12 Impact factor: 5.422

6. Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2.

Authors: A Altman; A N Theofilopoulos; R Weiner; D H Katz; F J Dixon
Journal: J Exp Med Date: 1981-09-01 Impact factor: 14.307

7. Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression.

Authors: M A Vadas; J F Miller; I F McKenzie; S E Chism; F W Shen; E A Boyse; J R Gamble; A M Whitelaw
Journal: J Exp Med Date: 1976-07-01 Impact factor: 14.307

8. Distribution of lymphocytes identified by surface markers in murine strains with systemic lupus erythematosus-like syndromes.

Authors: A N Theofilopoulos; R A Eisenberg; M Bourdon; J S Crowell; F J Dixon
Journal: J Exp Med Date: 1979-02-01 Impact factor: 14.307

Analysis of defective delayed-type hypersensitivity in autoimmune mice bearing lpr gene.

1. Genetic control of granuloma response to oil-associated BCG cell wall vaccine in mice.

2. Production of an antibody against guinea pig MIF. III. Biological activity of MIF recovered from immunoadsorbent column chromatography.

3. Duration of immunity to tuberculosis in mice vaccinated intravenously with oil-treated cell walls of Mycobacterium bovis strain BCG.

4. Spontaneous production of interleukin 3 by T lymphocytes from autoimmune MRL/MP-lpr/lpr mice.

5. Interleukin 2 deficiency is a common feature of autoimmune mice.

6. Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2.

7. Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression.

8. Distribution of lymphocytes identified by surface markers in murine strains with systemic lupus erythematosus-like syndromes.

9. Effect of helper T cells on the primary in vitro production of delayed-type hypersensitivity to influenza virus.

10. Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice bearing the lpr gene.

1. Lung lymphocyte elimination by apoptosis in the murine response to intratracheal particulate antigen.

2. Relationship of macrophages to defective delayed-type hypersensitivity in B6/lpr mice.