Literature DB >> 6975325

Interleukin 2 deficiency is a common feature of autoimmune mice.

M J Dauphinée, S B Kipper, D Wofsy, N Talal.   

Abstract

IL 2 production was studied in autoimmune mice to assess the role of this lymphokine in the pathogenesis of murine lupus. Spleen and lymph node cells from autoimmune-susceptible mice show an age-dependent loss in the ability to produce functional IL 2. This defect correlates with disease expression and is most severe in MLR/Mp-Ipr/Ipr mice. MLR/Mp-Ipr/Ipr thymocytes gradually lose responsiveness to IL 2 with age. These results suggest that the immunoregulatory abnormalities of autoimmune mice may be due in part to IL 2 deficiency.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 6975325

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  58 in total

Review 1.  Tumour necrosis factor and other cytokines in murine lupus.

Authors:  A N Theofilopoulos; B R Lawson
Journal:  Ann Rheum Dis       Date:  1999-11       Impact factor: 19.103

2.  Migration of carbon-laden peritoneal macrophages into the thymus of autoimmune New Zealand mice.

Authors:  J Ohmori; K Miyakawa; M Kotani
Journal:  J Anat       Date:  1989-08       Impact factor: 2.610

3.  Interleukin-2 production in Brown-Norway rats with HgCl2-induced autoimmune disease: paradoxical in vivo versus in vitro findings.

Authors:  D Baran; O Lantz; P Dosquet; A Sfaksi; P Druet
Journal:  Clin Exp Immunol       Date:  1988-09       Impact factor: 4.330

4.  Spontaneous recovery of the decreased expression in vitro of interleukin 2 receptors in rheumatoid arthritis.

Authors:  C Plater-Zyberk; K A Rockett; R N Maini
Journal:  Clin Exp Immunol       Date:  1988-07       Impact factor: 4.330

5.  The role of autoreactive T-cell hybridomas from autoimmune model mice.

Authors:  S Yanoma; I Aoki; N Ishii; K Tani; C S David; K Okuda
Journal:  Immunology       Date:  1988-05       Impact factor: 7.397

6.  Defective in vitro IL-2 production in lupus is an early but secondary event paralleling disease activity: evidence from the murine parent-into-F1 model supports staging of IL-2 defects in human lupus.

Authors:  Charles S Via; Gene M Shearer
Journal:  Autoimmunity       Date:  2010-02       Impact factor: 2.815

7.  Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus.

Authors:  Jens Y Humrich; Henner Morbach; Reinmar Undeutsch; Philipp Enghard; Stefan Rosenberger; Olivia Weigert; Lutz Kloke; Juliane Heimann; Timo Gaber; Susan Brandenburg; Alexander Scheffold; Jochen Huehn; Andreas Radbruch; Gerd-Rüdiger Burmester; Gabriela Riemekasten
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-14       Impact factor: 11.205

8.  Expression of Th1/Th2 cytokine mRNA in peritoneal exudative polymorphonuclear neutrophils and their effects on mononuclear cell Th1/Th2 cytokine production in MRL-lpr/lpr mice.

Authors:  C Yu; K Sun; C Tsai; Y Tsai; S Tsai; D Huang; S Han; H Yu
Journal:  Immunology       Date:  1998-11       Impact factor: 7.397

9.  Influence of dose and route of Mycobacterium lepraemurium inoculation on the production of interleukin 1 and interleukin 2 in C57BL/6 mice.

Authors:  A Hoffenbach; P H Lagrange; M A Bach
Journal:  Infect Immun       Date:  1984-06       Impact factor: 3.441

10.  Increased Ia expression, T lymphocyte subset abnormalities and autoimmunity in murine strains bearing the lpr gene.

Authors:  M J Dauphinée; N Talal
Journal:  Clin Exp Immunol       Date:  1984-10       Impact factor: 4.330
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.