Literature DB >> 29374632

Cryptococcal meningitis in a daily cannabis smoker without evidence of immunodeficiency.

Bryan B Shapiro1,2, Rebecca Hedrick2, Brigitte C Vanle2, Courtney A Becker3, Chris Nguyen3, David M Underhill3, Margie A Morgan4, Joel D Kopple5,6,7, Itai Danovitch2, Waguih William IsHak2,6.   

Abstract

Cryptococcal meningitis is a life-threatening condition most commonly observed in immunocompromised individuals. We describe a daily cannabis smoker without evidence of immunodeficiency presenting with confirmed Cryptococcus neoformans meningitis. An investigation of cannabis samples from the patient's preferred dispensary demonstrated contamination with several varieties of Cryptococcus, including C. neoformans, and other opportunistic fungi. These findings raise concern regarding the safety of dispensary-grade cannabis, even in immunocompetent users. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Entities:  

Keywords:  disease and health outcomes; drugs misuse (including addiction); exposures; healthcare improvement and patient safety; infectious diseases

Mesh：

Year:  2018        PMID： 29374632      PMCID： PMC5787011          DOI： 10.1136/bcr-2017-221435

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


  17 in total

1.  Immunological Consequences of Intestinal Fungal Dysbiosis.

Authors:  Matthew L Wheeler; Jose J Limon; Agnieszka S Bar; Christian A Leal; Matthew Gargus; Jie Tang; Jordan Brown; Vincent A Funari; Hanlin L Wang; Timothy R Crother; Moshe Arditi; David M Underhill; Iliyan D Iliev
Journal:  Cell Host Microbe       Date:  2016-05-26       Impact factor: 21.023

2.  Cryptococcosis in human immunodeficiency virus-negative patients in the era of effective azole therapy.

Authors:  P G Pappas; J R Perfect; G A Cloud; R A Larsen; G A Pankey; D J Lancaster; H Henderson; C A Kauffman; D W Haas; M Saccente; R J Hamill; M S Holloway; R M Warren; W E Dismukes
Journal:  Clin Infect Dis       Date:  2001-07-26       Impact factor: 9.079

3.  A microbiome assessment of medical marijuana.

Authors:  G R Thompson; J M Tuscano; M Dennis; A Singapuri; S Libertini; R Gaudino; A Torres; J M P Delisle; J D Gillece; J M Schupp; D M Engelthaler
Journal:  Clin Microbiol Infect       Date:  2016-12-09       Impact factor: 8.067

Review 4.  Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy.

Authors:  Peter R Williamson; Joseph N Jarvis; Anil A Panackal; Matthew C Fisher; Síle F Molloy; Angela Loyse; Thomas S Harrison
Journal:  Nat Rev Neurol       Date:  2016-11-25       Impact factor: 42.937

5.  Rapid identification of Cryptococcus neoformans and Cryptococcus gattii by matrix-assisted laser desorption ionization-time of flight mass spectrometry.

Authors:  Lisa R McTaggart; Eric Lei; Susan E Richardson; Linda Hoang; Annette Fothergill; Sean X Zhang
Journal:  J Clin Microbiol       Date:  2011-06-08       Impact factor: 5.948

6.  Cigarette smoking and mechanisms of susceptibility to infections of the respiratory tract and other organ systems.

Authors:  Charles Feldman; Ronald Anderson
Journal:  J Infect       Date:  2013-05-21       Impact factor: 6.072

Review 7.  Marijuana use and brain immune mechanisms.

Authors:  Guy A Cabral; Melissa Jamerson
Journal:  Int Rev Neurobiol       Date:  2014       Impact factor: 3.230

Review 8.  Successfully treated invasive pulmonary aspergillosis associated with smoking marijuana in a renal transplant recipient.

Authors:  W H Marks; L Florence; J Lieberman; P Chapman; D Howard; P Roberts; D Perkinson
Journal:  Transplantation       Date:  1996-06-27       Impact factor: 4.939

9.  Allergenic fungi and actinomycetes in smoking materials and their health implications.

Authors:  V P Kurup; A Resnick; S L Kagen; S H Cohen; J N Fink
Journal:  Mycopathologia       Date:  1983-04-22       Impact factor: 2.574

10.  Cannabis microbiome sequencing reveals several mycotoxic fungi native to dispensary grade Cannabis flowers.

Authors:  Kevin McKernan; Jessica Spangler; Lei Zhang; Vasisht Tadigotla; Yvonne Helbert; Theodore Foss; Douglas Smith
Journal:  F1000Res       Date:  2015-12-10
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  5 in total

1.  Methamphetamine Impairs IgG1-Mediated Phagocytosis and Killing of Cryptococcus neoformans by J774.16 Macrophage- and NR-9640 Microglia-Like Cells.

Authors:  Lilit Aslanyan; Hiu H Lee; Vaibhav V Ekhar; Raddy L Ramos; Luis R Martinez
Journal:  Infect Immun       Date:  2019-01-24       Impact factor: 3.441

2.  Cannabis Use and Fungal Infections in a Commercially Insured Population, United States, 2016.

Authors:  Kaitlin Benedict; George R Thompson; Brendan R Jackson
Journal:  Emerg Infect Dis       Date:  2020-06       Impact factor: 6.883

Review 3.  Current Landscape of Coccidioidomycosis.

Authors:  Ryan Boro; Prema C Iyer; Maciej A Walczak
Journal:  J Fungi (Basel)       Date:  2022-04-17

Review 4.  Scientific Prospects for Cannabis-Microbiome Research to Ensure Quality and Safety of Products.

Authors:  Vladimir Vujanovic; Darren R Korber; Silva Vujanovic; Josko Vujanovic; Suha Jabaji
Journal:  Microorganisms       Date:  2020-02-20

5.  Surgical treatment and operation time in human immunodeficiency virus-negative cryptococcal meningitis.

Authors:  Jie Zhao; Xiang Zhao; Shaobo Yang; Shuying Miao; Ying Liu
Journal:  Medicine (Baltimore)       Date:  2020-10-16       Impact factor: 1.817
  5 in total

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