OBJECTIVES: Metformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant and anti-inflammatory properties. The present study investigated the possible effect of Met on the D-galactose (D-gal)-induced aging in mice. MATERIALS AND METHODS: Met (1 and 10 mg/kg/p.o.), was administrated daily in D-gal-received (500 mg/kg/p.o.) mice model of aging for six weeks. Anxiety-like behavior, cognitive function, and physical power were evaluated by the elevated plus-maze, novel object recognition task (NORT), and forced swimming capacity test, respectively. The brains were analyzed for the level of superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF). RESULTS: Met decreased the anxiety-like behavior in D-gal-treated mice. Also, Met treated mice showed significantly improved learning and memory ability in NORT compared to the D-gal-treated mice. Furthermore, Met increased the physical power as well as the activity of SOD and BDNF level in D-gal-treated mice. CONCLUSION: Our results suggest that the use of Met can be an effective strategy for prevention and treatment of D-gal-induced aging in animal models. This effect seems to be mediated by attenuation of oxidative stress and enhancement of the neurotrophic factors.
OBJECTIVES: Metformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant and anti-inflammatory properties. The present study investigated the possible effect of Met on the D-galactose (D-gal)-induced aging in mice. MATERIALS AND METHODS: Met (1 and 10 mg/kg/p.o.), was administrated daily in D-gal-received (500 mg/kg/p.o.) mice model of aging for six weeks. Anxiety-like behavior, cognitive function, and physical power were evaluated by the elevated plus-maze, novel object recognition task (NORT), and forced swimming capacity test, respectively. The brains were analyzed for the level of superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF). RESULTS: Met decreased the anxiety-like behavior in D-gal-treated mice. Also, Met treated mice showed significantly improved learning and memory ability in NORT compared to the D-gal-treated mice. Furthermore, Met increased the physical power as well as the activity of SOD and BDNF level in D-gal-treated mice. CONCLUSION: Our results suggest that the use of Met can be an effective strategy for prevention and treatment of D-gal-induced aging in animal models. This effect seems to be mediated by attenuation of oxidative stress and enhancement of the neurotrophic factors.
Authors: Mohammad Zamanian; Mohammad R Hajizadeh; Ali Esmaeili Nadimi; Ali Shamsizadeh; Mohammad Allahtavakoli Journal: Fundam Clin Pharmacol Date: 2017-04-04 Impact factor: 2.748
Authors: Wilma Helena Oliveira; Ana Karolina Nunes; Maria Eduarda Rocha França; Laise Aline Santos; Deniele Bezerra Lós; Sura Wanessa Rocha; Karla Patrícia Barbosa; Gabriel Barros Rodrigues; Christina Alves Peixoto Journal: Brain Res Date: 2016-05-10 Impact factor: 3.252
Authors: S E Meshkani; D Mahdian; K Abbaszadeh-Goudarzi; M Abroudi; G Dadashizadeh; J-D Lalau; M E De Broe; H Hosseinzadeh Journal: J Endocrinol Invest Date: 2019-05-16 Impact factor: 4.256