S E Meshkani1, D Mahdian1,2, K Abbaszadeh-Goudarzi1,3, M Abroudi1, G Dadashizadeh1, J-D Lalau4, M E De Broe5, H Hosseinzadeh6,7. 1. Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran. 2. Department of Pharmacology, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran. 3. Department of Biochemistry, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran. 4. Department of Endocrinology, Université de Picardie Jules Verne, Amiens, France. 5. Department of Biomedical Sciences, Universiteit Antwerpen, Antwerp, Belgium. 6. Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. hosseinzadehh@mums.ac.ir. 7. Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. hosseinzadehh@mums.ac.ir.
Abstract
BACKGROUND: Metformin is the first prescribed drug for hyperglycemia in type 2 diabetes mellitus. Mainly by activating AMPK pathway, this drug exerts various functions that among them protective effects are of the interest. PURPOSE: Herein, we aimed to gather data about the protective impacts of metformin against various natural or chemical toxicities. RESULTS: An extensive search among PubMed, Scopus, and Google Scholar was conducted by keywords related to protection, toxicity, natural and chemical toxins and, metformin. Our literature review showed metformin alongside its anti-hyperglycemic effect has a wide range of anti-toxic effects against anti-tumour and routine drugs, natural and chemical toxins, herbicides and, heavy metals. CONCLUSION: It is evident that metformin is a potent drug against the toxicity of a broad spectrum of natural, chemical toxic agents which is proved by a vast number of studies. Metformin mainly through AMPK axis can protect different organs against toxicities. Moreover, metformin preserves DNA integrity and can be an option for adjuvant therapy to ameliorate side effect of other therapeutics.
BACKGROUND:Metformin is the first prescribed drug for hyperglycemia in type 2 diabetes mellitus. Mainly by activating AMPK pathway, this drug exerts various functions that among them protective effects are of the interest. PURPOSE: Herein, we aimed to gather data about the protective impacts of metformin against various natural or chemical toxicities. RESULTS: An extensive search among PubMed, Scopus, and Google Scholar was conducted by keywords related to protection, toxicity, natural and chemical toxins and, metformin. Our literature review showed metformin alongside its anti-hyperglycemic effect has a wide range of anti-toxic effects against anti-tumour and routine drugs, natural and chemical toxins, herbicides and, heavy metals. CONCLUSION: It is evident that metformin is a potent drug against the toxicity of a broad spectrum of natural, chemical toxic agents which is proved by a vast number of studies. Metformin mainly through AMPK axis can protect different organs against toxicities. Moreover, metformin preserves DNA integrity and can be an option for adjuvant therapy to ameliorate side effect of other therapeutics.
Entities:
Keywords:
Chemical toxin; Metformin protection; Natural toxin; Toxin
Authors: Adriana K Burlá; Núbia S Lobato; Zuleica B Fortes; Wille Oigman; Mario Fritsch Neves Journal: Int J Cardiol Date: 2011-09-25 Impact factor: 4.164