Z Xiao1, Z Tang2, J Qiang3, S Wang4, W Qian1, Y Zhong3, R Wang1, J Wang5, L Wu6, W Tang7, Z Zhang7. 1. From the Departments of Radiology (Z.X., Z.T., W.Q., R.W.). 2. From the Departments of Radiology (Z.X., Z.T., W.Q., R.W.) tzh518sunny@163.com wangshuyi@eent.shmu.edu.cnl. 3. Department of Radiology (J.Q., Y.Z.), Jinshan Hospital of Shanghai Medical School, Fudan University, Shanghai, P. R. China. 4. Pathology (S.W.) tzh518sunny@163.com wangshuyi@eent.shmu.edu.cnl. 5. Radiotherapy (J.W.). 6. Otolaryngology (L.W.), Eye & ENT Hospital of Shanghai Medical School, Fudan University, Shanghai, P. R. China. 7. Siemens Healthcare Ltd (W.T., Z.Z.), Shanghai, P. R. China.
Abstract
BACKGROUND AND PURPOSE: Intravoxel incoherent motion is a promising method for the differentiation of sinonasal lesions. This study aimed to evaluate the value of intravoxel incoherent motion in the differentiation of benign and malignant sinonasal lesions and to compare the diagnostic performance of intravoxel incoherent motion with that of conventional DWI. MATERIALS AND METHODS: One hundred thirty-one patients with histologically proved solid sinonasal lesions (56 benign and 75 malignant) who underwent conventional DWI and intravoxel incoherent motion were recruited in this study. The diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) values derived from intravoxel incoherent motion and ADC values derived from conventional DWI were measured and compared between the 2 groups using the Student t test. Receiver operating characteristic curve analysis, logistic regression analysis, and 10-fold cross-validation were performed to evaluate the diagnostic performance of single-parametric and multiparametric models. RESULTS: The mean ADC and D values were significantly lower in malignant sinonasal lesions than in benign sinonasal lesions (both P < .001). The mean f value was higher in malignant lesions than in benign lesions (P = .003). Multiparametric models can significantly improve the cross-validated areas under the curve for the differentiation of sinonasal lesions compared with single-parametric models (all corrected P < .05 except the D value). The model of D+f provided a better diagnostic performance than the ADC value (corrected P < .001). CONCLUSIONS: Intravoxel incoherent motion appears to be a more effective MR imaging technique than conventional DWI in the differentiation of benign and malignant sinonasal lesions.
BACKGROUND AND PURPOSE: Intravoxel incoherent motion is a promising method for the differentiation of sinonasal lesions. This study aimed to evaluate the value of intravoxel incoherent motion in the differentiation of benign and malignant sinonasal lesions and to compare the diagnostic performance of intravoxel incoherent motion with that of conventional DWI. MATERIALS AND METHODS: One hundred thirty-one patients with histologically proved solid sinonasal lesions (56 benign and 75 malignant) who underwent conventional DWI and intravoxel incoherent motion were recruited in this study. The diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) values derived from intravoxel incoherent motion and ADC values derived from conventional DWI were measured and compared between the 2 groups using the Student t test. Receiver operating characteristic curve analysis, logistic regression analysis, and 10-fold cross-validation were performed to evaluate the diagnostic performance of single-parametric and multiparametric models. RESULTS: The mean ADC and D values were significantly lower in malignant sinonasal lesions than in benign sinonasal lesions (both P < .001). The mean f value was higher in malignant lesions than in benign lesions (P = .003). Multiparametric models can significantly improve the cross-validated areas under the curve for the differentiation of sinonasal lesions compared with single-parametric models (all corrected P < .05 except the D value). The model of D+f provided a better diagnostic performance than the ADC value (corrected P < .001). CONCLUSIONS: Intravoxel incoherent motion appears to be a more effective MR imaging technique than conventional DWI in the differentiation of benign and malignant sinonasal lesions.
Authors: Hye-Jeong Lee; Sun Young Rha; Yong Eun Chung; Hyo Sub Shim; Young Jin Kim; Jin Hur; Yoo Jin Hong; Byoung Wook Choi Journal: Magn Reson Med Date: 2013-06-24 Impact factor: 4.668
Authors: Filippo Carta; Jean-Philippe Blancal; Benjamin Verillaud; Hugo Tran; Elisabeth Sauvaget; Romain Kania; Philippe Herman Journal: Head Neck Date: 2012-09-24 Impact factor: 3.147