Ana Martínez-Cañavate Burgos1, Javier Torres-Borrego2, Ana Belén Molina Terán2, Jose Luis Corzo3, Blanca Esther García4, Ramón Rodríguez Pacheco5, Carmen Moreno Aguilar6, Ignacio Dávila7. 1. Department of Pediatrics, Head of Pediatric Allergy Unit, H. Materno-Infantil Virgen de las Nieves, Granada, Spain. 2. Pediatric Allergy and Pulmonology Unit, Reina Sofia Children's University Hospital, Córdoba, Spain. 3. Pediatric Service, Carlos Haya Hospital, Málaga, Spain. 4. Complejo Hospitalario de Navarra, Pamplona, Spain. 5. Sección de Alergología. Hospital General Universitario de Elda, Elda (Alicante), Spain. 6. IMIBIC, Hospital Universitario Reina Sofia, ARADYAL, Córdoba, Spain. 7. Allergy Service and Department of Biomedical and Diagnostics Sciences, Institute for Biomedical Research of Salamanca (IBSAL), University Hospital of Salamanca, Salamanca, Spain.
Abstract
BACKGROUND: The overlapping grass and olive pollen seasons in Spain and the phenomenon of cross-reactivity can make it difficult to determine the true causative agent of seasonal allergic rhinitis when only skin prick tests with whole extracts are used. The aim of the GRAMOLE study was to determine sensitization patterns to the major grass and olive pollen allergens detected using specific recombinant IgE and to explore how this knowledge affected physicians' choice of allergen-specific immunotherapy. METHODS: Epidemiological, observational, multicenter, cross-sectional study. Results from children under 18 years of age diagnosed with seasonal allergic rhinitis by positive skin prick tests to olive and grass pollen were analyzed. Specific IgE to Phl p 1+5, Ole e 1, and Phl p 7+12 was determined. Investigators specified the optimal composition of allergen immunotherapy before and after knowing the results of the molecular diagnosis. RESULTS: A total of 281 patients with a mean age of 13.4 years were included. Double sensitization to both major allergens was found in vitro in 76% of children for an IgE cutoff point of 0.35 kU/L. When the molecular diagnosis results were known, specialists changed the composition of the prescribed immunotherapy in 52.87% of cases. CONCLUSIONS: Double sensitization to grass and olive pollen is common in Spain and also occurs in the pediatric population. Molecular diagnosis using specific IgE may help improve immunotherapy selection in polysensitized patients.
BACKGROUND: The overlapping grass and olive pollen seasons in Spain and the phenomenon of cross-reactivity can make it difficult to determine the true causative agent of seasonal allergic rhinitis when only skin prick tests with whole extracts are used. The aim of the GRAMOLE study was to determine sensitization patterns to the major grass and olive pollen allergens detected using specific recombinant IgE and to explore how this knowledge affected physicians' choice of allergen-specific immunotherapy. METHODS: Epidemiological, observational, multicenter, cross-sectional study. Results from children under 18 years of age diagnosed with seasonal allergic rhinitis by positive skin prick tests to olive and grass pollen were analyzed. Specific IgE to Phl p 1+5, Ole e 1, and Phl p 7+12 was determined. Investigators specified the optimal composition of allergen immunotherapy before and after knowing the results of the molecular diagnosis. RESULTS: A total of 281 patients with a mean age of 13.4 years were included. Double sensitization to both major allergens was found in vitro in 76% of children for an IgE cutoff point of 0.35 kU/L. When the molecular diagnosis results were known, specialists changed the composition of the prescribed immunotherapy in 52.87% of cases. CONCLUSIONS: Double sensitization to grass and olive pollen is common in Spain and also occurs in the pediatric population. Molecular diagnosis using specific IgE may help improve immunotherapy selection in polysensitized patients.
Authors: Mariona Pascal; Carmen Moreno; Ignacio Dávila; Ana I Tabar; Joan Bartra; Moisés Labrador; Olga Luengo Journal: Clin Transl Allergy Date: 2021-08 Impact factor: 5.657
Authors: José Fernando Florido-López; Carmen Andreu-Balaguer; Carmelo Escudero; Marta Seoane-Rodríguez; Mercedes Hernández; Luis Ángel Navarro-Seisdedos; Miguel Torrecillas-Toro; Mónica Anton-Girones; Leticia Herrero-Lifona; Dorimar Brugaletta; Jesús Macías; Rafael Pineda; Maria Ángeles Lara; Julián López-Caballero; Maria José Rojas Journal: World Allergy Organ J Date: 2020-12-18 Impact factor: 4.084