Øyvind Skadberg1, Øyunn Kleiven2, Stein Ørn3, Magnus F Bjørkavoll-Bergseth4, Tor H Melberg2, Torbjørn Omland5, Kristin M Aakre6. 1. Laboratory of Clinical Biochemistry, Stavanger University Hospital, Stavanger, Norway. 2. Cardiology Department, Stavanger University Hospital, Stavanger, Norway. 3. Cardiology Department, Stavanger University Hospital, Stavanger, Norway; Department of Electrical Engineering and Computer Science, University of Stavanger, Stavanger, Norway. 4. Sandnes Municipal, Sandnes, Norway. 5. Division of Medicine, Akershus University Hospital, Oslo, Norway; Center for Heart Failure Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. 6. Hormone Laboratory, Haukeland University Hospital, Bergen, Norway; Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway. Electronic address: kristin.moberg.aakre@helse-bergen.no.
Abstract
BACKGROUND: The aim of this study was to investigate troponin (cTn) dynamics for both genders, compared the different release patterns to the gender specific 99th percentile and to current biomarker criteria for diagnosing myocardial infarction (MI). METHODS: Serum was collected from 97 recreational cyclists 24 h before and immediately, 3 and 24 h following a 91-km bike race. hs-cTnI (Abbott) and hs-cTnT (Roche) were measured. Conventional or CT coronary angiography was performed in the 13 participants with the highest hs-cTnI (>140 ng/L). Three subjects with obstructive coronary artery disease were excluded from the statistical analysis. RESULTS: There was a significant (p < 0.001) post-race increase in cTnI and cTnT; cTnT peaked immediately, cTnI peaked after 3 h. Relative to the gender specific 99th percentile values, women had the largest increase. The biomarker criteria for MI were met in 76-87% for hs-cTnI, and 96-95% for hs-cTnT (p value <0.05), within the first 3 h post-race. CONCLUSION: Post-race cardiac troponin concentrations exceeded diagnostic criteria for MI in the majority of subjects, more often for hs-cTnT than for hs-cTnI, and more pronounced in women than in men. The current biomarker criteria for MI discriminate poorly between an exercise induced troponin increase and acute MI.
BACKGROUND: The aim of this study was to investigate troponin (cTn) dynamics for both genders, compared the different release patterns to the gender specific 99th percentile and to current biomarker criteria for diagnosing myocardial infarction (MI). METHODS: Serum was collected from 97 recreational cyclists 24 h before and immediately, 3 and 24 h following a 91-km bike race. hs-cTnI (Abbott) and hs-cTnT (Roche) were measured. Conventional or CT coronary angiography was performed in the 13 participants with the highest hs-cTnI (>140 ng/L). Three subjects with obstructive coronary artery disease were excluded from the statistical analysis. RESULTS: There was a significant (p < 0.001) post-race increase in cTnI and cTnT; cTnT peaked immediately, cTnI peaked after 3 h. Relative to the gender specific 99th percentile values, women had the largest increase. The biomarker criteria for MI were met in 76-87% for hs-cTnI, and 96-95% for hs-cTnT (p value <0.05), within the first 3 h post-race. CONCLUSION: Post-race cardiac troponin concentrations exceeded diagnostic criteria for MI in the majority of subjects, more often for hs-cTnT than for hs-cTnI, and more pronounced in women than in men. The current biomarker criteria for MI discriminate poorly between an exercise induced troponin increase and acute MI.
Authors: Henning O Ness; Kristine Ljones; Randi H Gjelsvik; Arnt Erik Tjønna; Vegard Malmo; Hans Olav Nilsen; Siri Marte Hollekim-Strand; Håvard Dalen; Morten Andre Høydal Journal: Sci Rep Date: 2022-05-17 Impact factor: 4.996
Authors: Vincent L Aengevaeren; Aaron L Baggish; Eugene H Chung; Keith George; Øyunn Kleiven; Alma M A Mingels; Stein Ørn; Rob E Shave; Paul D Thompson; Thijs M H Eijsvogels Journal: Circulation Date: 2021-12-13 Impact factor: 29.690
Authors: Caroline Le Goff; Magalie Viallon; Jean-François Kaux; Pierre Andonian; Kevin Moulin; Laurence Seidel; Guido Giardini; Laurent Gergelé; Pierre Croisille; Etienne Cavalier; Gregoire P Millet Journal: Front Cardiovasc Med Date: 2022-03-07