Literature DB >> 29366606

PRDM9 and Its Role in Genetic Recombination.

Kenneth Paigen1, Petko M Petkov2.   

Abstract

PRDM9 is a zinc finger protein that binds DNA at specific locations in the genome where it trimethylates histone H3 at lysines 4 and 36 at surrounding nucleosomes. During meiosis in many species, including humans and mice where PRDM9 has been most intensely studied, these actions determine the location of recombination hotspots, where genetic recombination occurs. In addition, PRDM9 facilitates the association of hotspots with the chromosome axis, the site of the programmed DNA double-strand breaks (DSBs) that give rise to genetic exchange between chromosomes. In the absence of PRDM9 DSBs are not properly repaired. Collectively, these actions determine patterns of genetic linkage and the possibilities for chromosome reorganization over successive generations.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  PRDM9; meiosis; recombination

Mesh：

Substances：

Year:  2018        PMID： 29366606      PMCID： PMC5878713          DOI： 10.1016/j.tig.2017.12.017

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  95 in total

Review 1.  Mammalian recombination hot spots: properties, control and evolution.

Authors:  Kenneth Paigen; Petko Petkov
Journal:  Nat Rev Genet       Date:  2010-03       Impact factor: 53.242

2.  Recombination regulator PRDM9 influences the instability of its own coding sequence in humans.

Authors:  Alec J Jeffreys; Victoria E Cotton; Rita Neumann; Kwan-Wood Gabriel Lam
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-24       Impact factor: 11.205

Review 3.  End-labeling and analysis of Spo11-oligonucleotide complexes in Saccharomyces cerevisiae.

Authors:  Matthew J Neale; Scott Keeney
Journal:  Methods Mol Biol       Date:  2009

4.  Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome.

Authors:  Erik Axelsson; Matthew T Webster; Abhirami Ratnakumar; Chris P Ponting; Kerstin Lindblad-Toh
Journal:  Genome Res       Date:  2011-10-17       Impact factor: 9.043

5.  Prdm9, a major determinant of meiotic recombination hotspots, is not functional in dogs and their wild relatives, wolves and coyotes.

Authors:  Violeta Muñoz-Fuentes; Anna Di Rienzo; Carles Vilà
Journal:  PLoS One       Date:  2011-11-10       Impact factor: 3.240

6.  Prdm9 polymorphism unveils mouse evolutionary tracks.

Authors:  Hiromitsu Kono; Masaru Tamura; Naoki Osada; Hitoshi Suzuki; Kuniya Abe; Kazuo Moriwaki; Kunihiro Ohta; Toshihiko Shiroishi
Journal:  DNA Res       Date:  2014-01-20       Impact factor: 4.458

7.  Hybrid Sterility Locus on Chromosome X Controls Meiotic Recombination Rate in Mouse.

Authors:  Maria Balcova; Barbora Faltusova; Vaclav Gergelits; Tanmoy Bhattacharyya; Ondrej Mihola; Zdenek Trachtulec; Corinna Knopf; Vladana Fotopulosova; Irena Chvatalova; Sona Gregorova; Jiri Forejt
Journal:  PLoS Genet       Date:  2016-04-22       Impact factor: 5.917

8.  A Pedigree-Based Map of Recombination in the Domestic Dog Genome.

Authors:  Christopher L Campbell; Claude Bhérer; Bernice E Morrow; Adam R Boyko; Adam Auton
Journal:  G3 (Bethesda)       Date:  2016-11-08       Impact factor: 3.154

9.  In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites.

Authors:  Corinne Grey; Julie A J Clément; Jérôme Buard; Benjamin Leblanc; Ivo Gut; Marta Gut; Laurent Duret; Bernard de Massy
Journal:  Genome Res       Date:  2017-03-23       Impact factor: 9.043

10.  The evolutionary turnover of recombination hot spots contributes to speciation in mice.

Authors:  Fatima Smagulova; Kevin Brick; Yongmei Pu; R Daniel Camerini-Otero; Galina V Petukhova
Journal:  Genes Dev       Date:  2016-02-01       Impact factor: 11.361
View more
  35 in total

1.  Extreme clustering of type-1 NF1 deletion breakpoints co-locating with G-quadruplex forming sequences.

Authors:  Anna Summerer; Victor-Felix Mautner; Meena Upadhyaya; Kathleen B M Claes; Josef Högel; David N Cooper; Ludwine Messiaen; Hildegard Kehrer-Sawatzki
Journal:  Hum Genet       Date:  2018-07-10       Impact factor: 4.132

2.  Population-Specific Recombination Maps from Segments of Identity by Descent.

Authors:  Ying Zhou; Brian L Browning; Sharon R Browning
Journal:  Am J Hum Genet       Date:  2020-06-12       Impact factor: 11.025

3.  Chromosome-wide characterization of meiotic noncrossovers (gene conversions) in mouse hybrids.

Authors:  Vaclav Gergelits; Emil Parvanov; Petr Simecek; Jiri Forejt
Journal:  Genetics       Date:  2021-03-03       Impact factor: 4.562

4.  Haplotype structures and polymorphisms of dog leukocyte antigen (DLA) class I loci shaped by intralocus and interlocus recombination events.

Authors:  Jiro Miyamae; Masaharu Okano; Kohei Nishiya; Fumihiko Katakura; Jerzy K Kulski; Tadaaki Moritomo; Takashi Shiina
Journal:  Immunogenetics       Date:  2022-01-07       Impact factor: 2.846

Review 5.  Crossover patterning in plants.

Authors:  Andrew Lloyd
Journal:  Plant Reprod       Date:  2022-07-14       Impact factor: 4.217

6.  Genic and chromosomal components of Prdm9-driven hybrid male sterility in mice (Mus musculus).

Authors:  Barbora Valiskova; Sona Gregorova; Diana Lustyk; Petr Šimeček; Petr Jansa; Jiří Forejt
Journal:  Genetics       Date:  2022-08-30       Impact factor: 4.402

7.  Genetic Dissection of Hybrid Male Sterility Across Stages of Spermatogenesis.

Authors:  Denise J Schwahn; Richard J Wang; Michael A White; Bret A Payseur
Journal:  Genetics       Date:  2018-10-17       Impact factor: 4.562

8.  Molecular evolution of the meiotic recombination pathway in mammals.

Authors:  Amy L Dapper; Bret A Payseur
Journal:  Evolution       Date:  2019-11-07       Impact factor: 3.694

9.  Fatal perinatal mitochondrial cardiac failure caused by recurrent de novo duplications in the ATAD3 locus.

Authors:  Ann E Frazier; Alison G Compton; Yoshihito Kishita; Daniella H Hock; AnneMarie E Welch; Sumudu S C Amarasekera; Rocio Rius; Luke E Formosa; Atsuko Imai-Okazaki; David Francis; Min Wang; Nicole J Lake; Simone Tregoning; Jafar S Jabbari; Alexis Lucattini; Kazuhiro R Nitta; Akira Ohtake; Kei Murayama; David J Amor; George McGillivray; Flora Y Wong; Marjo S van der Knaap; R Jeroen Vermeulen; Esko J Wiltshire; Janice M Fletcher; Barry Lewis; Gareth Baynam; Carolyn Ellaway; Shanti Balasubramaniam; Kaustuv Bhattacharya; Mary-Louise Freckmann; Susan Arbuckle; Michael Rodriguez; Ryan J Taft; Simon Sadedin; Mark J Cowley; André E Minoche; Sarah E Calvo; Vamsi K Mootha; Michael T Ryan; Yasushi Okazaki; David A Stroud; Cas Simons; John Christodoulou; David R Thorburn
Journal:  Med (N Y)       Date:  2020-07-09

Review 10.  The duality of PRDM proteins: epigenetic and structural perspectives.

Authors:  Federico Di Tullio; Megan Schwarz; Habiba Zorgati; Slim Mzoughi; Ernesto Guccione
Journal:  FEBS J       Date:  2021-05-19       Impact factor: 5.622
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.