| Literature DB >> 29364285 |
Elisa Laurenti1, Berthold Göttgens1.
Abstract
The development of mature blood cells from haematopoietic stem cells has long served as a model for stem-cell research, with the haematopoietic differentiation tree being widely used as a model for the maintenance of hierarchically organized tissues. Recent results and new technologies have challenged the demarcations between stem and progenitor cell populations, the timing of cell-fate choices and the contribution of stem and multipotent progenitor cells to the maintenance of steady-state blood production. These evolving views of haematopoiesis have broad implications for our understanding of the functions of adult stem cells, as well as the development of new therapies for malignant and non-malignant haematopoietic diseases.Entities:
Mesh:
Year: 2018 PMID: 29364285 PMCID: PMC6555401 DOI: 10.1038/nature25022
Source DB: PubMed Journal: Nature ISSN: 0028-0836 Impact factor: 49.962