Yoshimi Tatsukawa1, Munechika Misumi2, Young Min Kim2,3, Michiko Yamada4, Waka Ohishi4, Saeko Fujiwara5, Shuhei Nakanishi6, Masayasu Yoneda7. 1. Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan. tktatsu@rerf.or.jp. 2. Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan. 3. Department of Statistics, Kyungpook National University, Daegu, Korea. 4. Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan. 5. Hiroshima Atomic Bomb Casualty Council, Hiroshima, Japan. 6. Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Kurashiki, Japan. 7. Department of Molecular and Internal Medicine, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Abstract
BACKGROUND/ OBJECTIVES: Few longitudinal studies have examined the association between diabetes risk and body composition in Asians. The aim of this prospective cohort study was to determine the role of body composition, estimated by whole-body dual-energy X-ray absorptiometry, in the development of diabetes and to examine the impact of body composition on diabetes risk in normal weight (body mass index (BMI) <23 kg/m2) and overweight/obese groups (≥23 kg/m2). SUBJECTS/ METHODS: We measured the body composition for 1532 diabetes-free subjects (463 men and 1069 women), aged 48-79 years, at the baseline examination period from 1994-96 and followed-up to detect new cases of diabetes over the next 15 years (median 13.4 years). RESULTS: After being adjusted for BMI and other potential confounding factors, body fat distribution was associated with diabetes risk. Percentage of trunk fat was positively associated with the development of diabetes (hazards ratio (HR) per 1 SD (95% confidential interval (CI)), 1.58 (1.10-2.28) in men, and 1.34 (0.99-1.83) in women), and percentage of leg fat was negatively associated with the development of diabetes (HR per 1 SD (95% CI), 0.68 (0.50-0.91) in men and 0.68 (0.55-0.85) in women). The estimated HRs of % trunk and leg fat on the development of diabetes differed little between normal weight and overweight/obese subjects. Appendicular lean mass was also negatively associated with diabetes risk only in normal weight men. CONCLUSIONS: Opposite associations of trunk fat and leg fat with diabetes risk were observed. Assessment of body composition might help in the evaluation of diabetes risk.
BACKGROUND/ OBJECTIVES: Few longitudinal studies have examined the association between diabetes risk and body composition in Asians. The aim of this prospective cohort study was to determine the role of body composition, estimated by whole-body dual-energy X-ray absorptiometry, in the development of diabetes and to examine the impact of body composition on diabetes risk in normal weight (body mass index (BMI) <23 kg/m2) and overweight/obese groups (≥23 kg/m2). SUBJECTS/ METHODS: We measured the body composition for 1532 diabetes-free subjects (463 men and 1069 women), aged 48-79 years, at the baseline examination period from 1994-96 and followed-up to detect new cases of diabetes over the next 15 years (median 13.4 years). RESULTS: After being adjusted for BMI and other potential confounding factors, body fat distribution was associated with diabetes risk. Percentage of trunk fat was positively associated with the development of diabetes (hazards ratio (HR) per 1 SD (95% confidential interval (CI)), 1.58 (1.10-2.28) in men, and 1.34 (0.99-1.83) in women), and percentage of leg fat was negatively associated with the development of diabetes (HR per 1 SD (95% CI), 0.68 (0.50-0.91) in men and 0.68 (0.55-0.85) in women). The estimated HRs of % trunk and leg fat on the development of diabetes differed little between normal weight and overweight/obese subjects. Appendicular lean mass was also negatively associated with diabetes risk only in normal weight men. CONCLUSIONS: Opposite associations of trunk fat and leg fat with diabetes risk were observed. Assessment of body composition might help in the evaluation of diabetes risk.
Authors: Guo-Chong Chen; Rhonda Arthur; Neil M Iyengar; Victor Kamensky; Xiaonan Xue; Sylvia Wassertheil-Smoller; Matthew A Allison; Aladdin H Shadyab; Robert A Wild; Yangbo Sun; Hailey R Banack; Jin Choul Chai; Jean Wactawski-Wende; JoAnn E Manson; Marcia L Stefanick; Andrew J Dannenberg; Thomas E Rohan; Qibin Qi Journal: Eur Heart J Date: 2019-09-07 Impact factor: 29.983
Authors: Asanda Mtintsilana; Lisa K Micklesfield; Elin Chorell; Tommy Olsson; Julia H Goedecke Journal: Nutr Diabetes Date: 2019-03-27 Impact factor: 5.097