Lucas Calais-Ferreira1, Vinicius C Oliveira2, Jeffrey M Craig3, Louisa B Flander4, John L Hopper4, Luci F Teixeira-Salmela5, Paulo H Ferreira6. 1. The University of Melbourne, Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, Melbourne, Victoria, Australia. Electronic address: lucas.cf@unimelb.edu.au. 2. Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Programa de Pós-Graduação em Reabilitação e Desempenho Funcional, Diamantina, MG, Brazil. 3. Deakin University, School of Medicine, Centre for Molecular and Medical Research, Geelong, Victoria, Australia; Royal Children's Hospital, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia; The University of Melbourne, Department of Paediatrics, Melbourne, Victoria, Australia. 4. The University of Melbourne, Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, Melbourne, Victoria, Australia. 5. Universidade Federal de Minas Gerais (UFMG), Departamento de Fisioterapia, Belo Horizonte, MG, Brazil. 6. The University of Sydney, Faculty of Health Sciences, Musculoskeletal Health Research Group, Sydney, New South Wales, Australia.
Abstract
BACKGROUND: Musculoskeletal conditions are highly prevalent in our ageing society and are therefore incurring substantial increases in population levels of years lived with disability (YLD). An evidence-based approach to the prognosis, prevention, and treatment of those disorders can allow an overall improvement in the quality of life of patients, while also softening the burden on national health care systems. METHODS: In this Masterclass article, we provide an overview of the most relevant twin study designs, their advantages, limitations and major contributions to the investigation of traits related to the domain of musculoskeletal physical therapy. CONCLUSIONS: Twin studies can be an important scientific tool to address issues related to musculoskeletal conditions. They allow researchers to understand how genes and environment combine to influence human health and disease. Twin registries and international collaboration through existing networks can provide resources for achieving large sample sizes and access to expertise in study design and analysis of twin data.
BACKGROUND:Musculoskeletal conditions are highly prevalent in our ageing society and are therefore incurring substantial increases in population levels of years lived with disability (YLD). An evidence-based approach to the prognosis, prevention, and treatment of those disorders can allow an overall improvement in the quality of life of patients, while also softening the burden on national health care systems. METHODS: In this Masterclass article, we provide an overview of the most relevant twin study designs, their advantages, limitations and major contributions to the investigation of traits related to the domain of musculoskeletal physical therapy. CONCLUSIONS: Twin studies can be an important scientific tool to address issues related to musculoskeletal conditions. They allow researchers to understand how genes and environment combine to influence human health and disease. Twin registries and international collaboration through existing networks can provide resources for achieving large sample sizes and access to expertise in study design and analysis of twin data.
Authors: Helen C McNamara; Stefan C Kane; Jeffrey M Craig; Roger V Short; Mark P Umstad Journal: Am J Obstet Gynecol Date: 2015-11-06 Impact factor: 8.661
Authors: Jenny van Dongen; P Eline Slagboom; Harmen H M Draisma; Nicholas G Martin; Dorret I Boomsma Journal: Nat Rev Genet Date: 2012-07-31 Impact factor: 53.242
Authors: Glen E Duncan; Jack Goldberg; Carolyn Noonan; Anne Vernez Moudon; Philip Hurvitz; Dedra Buchwald Journal: PLoS One Date: 2008-04-16 Impact factor: 3.240
Authors: Hercules R Leite; Amabile B Dario; Alison R Harmer; Vinicius C Oliveira; Manuela L Ferreira; Lucas Calais-Ferreira; Paulo H Ferreira Journal: Eur Spine J Date: 2018-12-06 Impact factor: 3.134
Authors: So Young Kim; Dae Myoung Yoo; Mi Jung Kwon; Ji Hee Kim; Joo-Hee Kim; Woo Jin Bang; Hyo Geun Choi Journal: J Clin Med Date: 2022-07-11 Impact factor: 4.964