| Literature DB >> 29361416 |
Hirofumi Toda1, Kaori Satoh2, Masaru Komatsu3, Saori Fukuda4, Tatsuya Nakamura5, Takumi Jikimoto5, Hisaaki Nishio6, Katsutoshi Yamasaki7, Takuya Maede8, Tamaki Orita9, Noriyuki Sueyoshi10, Machiko Kita10, Masahiro Toyokawa11, Isao Nishi12, Masahiro Akagi13, Takefumi Higuchi14, Tomomi Kofuku15, Isako Nakai15, Tamotsu Ono16, Koichi Shimakawa17, Yoshie Hikita17, Kunihiko Moro18, Kaneyuki Kida19, Masanobu Oohama19, Yasunao Wada20, Toru Tobe21, Toshinori Kamisako22, Yuji Tanaka22.
Abstract
The 7-valent pneumococcal conjugate vaccine (PCV7) was introduced among children in Japan in 2010. There are no long-term multicenter surveillance studies of antimicrobial resistance in S. pneumoniae before and after the introduction of PCV7. Therefore, we examined chronological trends in antimicrobial resistance among 4534 strains of S. pneumoniae isolated from both children and adults in the Kinki region of Japan during 2001-2015. High-level penicillin and third-generation cephalosporin resistance in S. pneumoniae increased among both children and adults during the period before the introduction of PCV7 (2001-2010). Besides penicillin and cephalosporin, pneumococcal carbapenem and macrolide resistance increased among children. The rate of resistance to these antibiotics was higher among children than among adults. The introduction of PCV7 decreased the rate of non-susceptibility to β-lactam antibiotics and the rate of multidrug resistant S. pneumoniae among children, but not among adults.Entities:
Keywords: Multidrug resistance; PCV7; Streptococcus pneumoniae
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Year: 2018 PMID： 29361416 DOI： 10.1016/j.jiac.2017.12.010
Source DB: PubMed Journal: J Infect Chemother ISSN： 1341-321X Impact factor: 2.211