Rosa de Miguel Buckley1, Rocio Montejano1, Natalia Stella-Ascariz1, Jose R Arribas2,3. 1. HIV Unit, Internal Medicine Service, Hospital Universitario La Paz-IdiPAZ, Madrid, Spain. 2. HIV Unit, Internal Medicine Service, Hospital Universitario La Paz-IdiPAZ, Madrid, Spain. joser.arribas@salud.madrid.org. 3. Edificio de Investigación IdiPAZ, Despacho 3.3, Hospital La Paz, IdiPAZ, Castellana 261, 28046, Madrid, Spain. joser.arribas@salud.madrid.org.
Abstract
PURPOSE OF REVIEW: Simplification of antiretroviral therapy is a strategy aiming to reduce pill burden, drug interactions, and toxicity. This review focuses on the most recent and important studies evaluating a reduction on the number of drugs for HIV treatment, both in naive and virologically suppressed patients. RECENT FINDINGS: Interesting studies have been performed in the past years testing dual therapy and monotherapy, with variable rates of virological control. Novel therapeutics like immunotherapy or long-acting antiretrovirals can also be considered for simplification. Reducing the number of drugs for HIV treatment can be an option for selected patients. Current available evidence favors dual therapy over monotherapy. Future research should seek to identify the best candidates for simplification.
PURPOSE OF REVIEW: Simplification of antiretroviral therapy is a strategy aiming to reduce pill burden, drug interactions, and toxicity. This review focuses on the most recent and important studies evaluating a reduction on the number of drugs for HIV treatment, both in naive and virologically suppressed patients. RECENT FINDINGS: Interesting studies have been performed in the past years testing dual therapy and monotherapy, with variable rates of virological control. Novel therapeutics like immunotherapy or long-acting antiretrovirals can also be considered for simplification. Reducing the number of drugs for HIV treatment can be an option for selected patients. Current available evidence favors dual therapy over monotherapy. Future research should seek to identify the best candidates for simplification.
Authors: P M Girard; A Antinori; J R Arribas; D Ripamonti; C Bicer; B Netzle-Sveine; B Hadacek; C Moecklinghoff Journal: HIV Med Date: 2016-06-09 Impact factor: 3.180
Authors: Ildefonso Pulido; Miguel Genebat; Ana I Alvarez-Rios; Rebeca S De Pablo-Bernal; Mohammed Rafii-El-Idrissi Benhnia; Yolanda M Pacheco; Ezequiel Ruiz-Mateos; Manuel Leal Journal: Viral Immunol Date: 2016-09-22 Impact factor: 2.257
Authors: Sarah Lilian Pett; Janaki Amin; Andrejz Horban; Jaime Andrade-Villanueva; Marcelo Losso; Norma Porteiro; Juan Sierra Madero; Waldo Belloso; Elise Tu; David Silk; Anthony Kelleher; Richard Harrigan; Andrew Clark; Wataru Sugiura; Marcelo Wolff; John Gill; Jose Gatell; Martin Fisher; Amanda Clarke; Kiat Ruxrungtham; Thierry Prazuck; Rolf Kaiser; Ian Woolley; Juan Alberto Arnaiz; David Cooper; Jürgen K Rockstroh; Patrick Mallon; Sean Emery Journal: Clin Infect Dis Date: 2016-04-05 Impact factor: 9.079
Authors: Nicholas I Paton; Wolfgang Stöhr; Alejandro Arenas-Pinto; Martin Fisher; Ian Williams; Margaret Johnson; Chloe Orkin; Fabian Chen; Vincent Lee; Alan Winston; Mark Gompels; Julie Fox; Karen Scott; David T Dunn Journal: Lancet HIV Date: 2015-09-14 Impact factor: 12.767
Authors: Pedro Cahn; María José Rolón; María Inés Figueroa; Ana Gun; Patricia Patterson; Omar Sued Journal: J Int AIDS Soc Date: 2017-05-09 Impact factor: 5.396
Authors: S Lambert-Niclot; E C George; A Pozniak; E White; C Schwimmer; H Jessen; M Johnson; D Dunn; C F Perno; B Clotet; A Plettenberg; A Blaxhult; L Palmisano; L Wittkop; V Calvez; A G Marcelin; F Raffi Journal: J Antimicrob Chemother Date: 2015-12-24 Impact factor: 5.790
Authors: Jose I Bernardino; Amanda Mocroft; Patrick W Mallon; Cedrick Wallet; Jan Gerstoft; Charlotte Russell; Peter Reiss; Christine Katlama; Stephane De Wit; Laura Richert; Abdel Babiker; Antonio Buño; Antonella Castagna; Pierre-Marie Girard; Genevieve Chene; Francois Raffi; Jose R Arribas Journal: Lancet HIV Date: 2015-09-30 Impact factor: 12.767
Authors: Santiago Jiménez de Ory; Carolina Beltrán-Pavez; Miguel Gutiérrez-López; María Del Mar Santos; Luis Prieto; Talía Sainz; Sara Guillen; David Aguilera-Alonso; Cristina Díez; Jose Ignacio Bernardino; María José Mellado; José Tomás Ramos; África Holguín; Marisa Navarro Journal: J Antimicrob Chemother Date: 2021-06-18 Impact factor: 5.790
Authors: Jesús Troya; Carlos Dueñas; Idoia Irazola; Ignacio de Los Santos; Sara de la Fuente; Desiré Gil; Cristina Hernández; María José Galindo; Julia Gómez; Elisabeth Delgado; Estela Moreno-García; Guillermo Posada; Teresa Aldámiz; Jose Antonio Iribarren; José Manuel Guerra; Miguel Ángel Morán; Carlos Galera; Javier Fuente; Ana Peláez; Miguel Cervero; María Garcinuño; Marta Montero; Francisco Ceballos; Luis Buzón Journal: Medicine (Baltimore) Date: 2022-06-17 Impact factor: 1.817