Beth E Snitz1, Tianxiu Wang2, Yona Keich Cloonan3, Erin Jacobsen2, Chung-Chou H Chang4, Tiffany F Hughes5, M Ilyas Kamboh6, Mary Ganguli7. 1. Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: snitzbe@upmc.edu. 2. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. 3. Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA. 4. Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. 5. Department of Gerontology, Youngstown State University, Youngstown, OH, USA. 6. Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA. 7. Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Abstract
INTRODUCTION: We compared risk of progression from subjective cognitive decline (SCD) to mild cognitive impairment (MCI) in an academic memory clinic versus a population-based study. METHODS: Older adults presenting at a memory clinic were classified as SCD (n = 113) or as noncomplainers (n = 82). Participants from a population study were classified as SCD (n = 592) and noncomplainers (n = 589) based on a memory complaint score. Annual follow-up performed for a mean of 3 years. RESULTS: The adjusted hazard ratio for SCD was 15.97 (95% confidence interval: 6.08-42.02, P < .001) in the memory clinic versus 1.18 (95% confidence interval: 1.00-1.40, P = .047) in the population study, where reported "worry" about memory further increased SCD-associated risk for MCI. DISCUSSION: SCD is more likely to progress to MCI in a memory clinic than the general population; participants' characteristics vary across settings. Study setting should be considered when evaluating SCD as a risk state for MCI and dementia.
INTRODUCTION: We compared risk of progression from subjective cognitive decline (SCD) to mild cognitive impairment (MCI) in an academic memory clinic versus a population-based study. METHODS: Older adults presenting at a memory clinic were classified as SCD (n = 113) or as noncomplainers (n = 82). Participants from a population study were classified as SCD (n = 592) and noncomplainers (n = 589) based on a memory complaint score. Annual follow-up performed for a mean of 3 years. RESULTS: The adjusted hazard ratio for SCD was 15.97 (95% confidence interval: 6.08-42.02, P < .001) in the memory clinic versus 1.18 (95% confidence interval: 1.00-1.40, P = .047) in the population study, where reported "worry" about memory further increased SCD-associated risk for MCI. DISCUSSION: SCD is more likely to progress to MCI in a memory clinic than the general population; participants' characteristics vary across settings. Study setting should be considered when evaluating SCD as a risk state for MCI and dementia.
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