Literature DB >> 29351622

Antimicrobial Peptide Resistance Mechanism Contributes to Staphylococcus aureus Infection.

Gordon Y C Cheung1, Emilie L Fisher1, Joshua W McCausland1, Justin Choi1, John W M Collins2, Seth W Dickey1, Michael Otto1.   

Abstract

Antimicrobial peptides (AMPs) constitute an important part of innate host defense. Possibly limiting the therapeutic potential of AMPs is the fact that bacteria have developed AMP resistance mechanisms during their co-evolution with humans. However, there is no direct evidence that AMP resistance per se is important during an infection. Here we show that the Staphylococcus aureus Pmt ABC transporter defends the bacteria from killing by important human AMPs and elimination by human neutrophils. By showing that Pmt contributes to virulence during skin infection in an AMP-dependent manner, we provide evidence that AMP resistance plays a key role in bacterial infection.

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Year:  2018        PMID： 29351622      PMCID： PMC5939666          DOI： 10.1093/infdis/jiy024

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  25 in total

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  10 in total

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