Can Li1, Jianqun Lin1, Ling Gao2, Huibin Lin3, Jianqiang Lin4. 1. State Key Laboratory of Microbial Technology, Microbiology Technology Institute, Shandong University, Jinan, 250100, China. 2. Institute of Information Science and Engineering, School of Information Science and Engineering, Shandong Normal University, Jinan, China. 3. Shandong Academy of Chinese Medicine, Jinan, China. 4. State Key Laboratory of Microbial Technology, Microbiology Technology Institute, Shandong University, Jinan, 250100, China. jianqianglin@sdu.edu.cn.
Abstract
OBJECTIVES: Production of gluconic acid by using immobilized enzyme and continuous stirred tank reactor-plug flow tubular reactor (CSTR-PFTR) circulation reaction system. RESULTS: A production system is constructed for gluconic acid production, which consists of a continuous stirred tank reactor (CSTR) for pH control and liquid storage and a plug flow tubular reactor (PFTR) filled with immobilized glucose oxidase (GOD) for gluconic acid production. Mathematical model is developed for this production system and simulation is made for the enzymatic reaction process. The pH inhibition effect on GOD is modeled by using a bell-type curve. CONCLUSIONS: Gluconic acid can be efficiently produced by using the reaction system and the mathematical model developed for this system can simulate and predict the process well.
OBJECTIVES: Production of gluconic acid by using immobilized enzyme and continuous stirred tank reactor-plug flow tubular reactor (CSTR-PFTR) circulation reaction system. RESULTS: A production system is constructed for gluconic acid production, which consists of a continuous stirred tank reactor (CSTR) for pH control and liquid storage and a plug flow tubular reactor (PFTR) filled with immobilized glucose oxidase (GOD) for gluconic acid production. Mathematical model is developed for this production system and simulation is made for the enzymatic reaction process. The pH inhibition effect on GOD is modeled by using a bell-type curve. CONCLUSIONS:Gluconic acid can be efficiently produced by using the reaction system and the mathematical model developed for this system can simulate and predict the process well.