Literature DB >> 29346216

Obesity and Pancreatic Cancer: Overview of Epidemiology and Potential Prevention by Weight Loss.

Mu Xu1, Xiaoman Jung, O Joe Hines, Guido Eibl, Yijun Chen.   

Abstract

Currently, there are no effective preventive strategies for pancreatic cancer. Obesity has been increasingly recognized as a strong but modifiable risk factor of pancreatic cancer. In this article, we aim to review the literature regarding weight loss on prevention of pancreatic cancer. Epidemiological and laboratory studies have shown that obesity is associated with increased incidence of pancreatic cancer and potentially worse cancer outcome. Whereas the underlying pathomechanisms remain unclear, chronic inflammation, insulin resistance, and altered intestinal microbiota are all implicated in the carcinogenic effect of obesity. Weight loss, especially the durable and significant weight loss after bariatric surgery, has been shown to reduce the risks of multiple cancers and may become a good intervention for pancreatic cancer prevention.

Entities:  

Mesh：

Year:  2018        PMID： 29346216      PMCID： PMC6018023          DOI： 10.1097/MPA.0000000000000974

Source DB:  PubMed          Journal:  Pancreas        ISSN： 0885-3177            Impact factor:   3.327


  74 in total

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Review 2.  Critical nodes in signalling pathways: insights into insulin action.

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3.  Effects of sleeve gastrectomy in high fat diet-induced obese mice: respective role of reduced caloric intake, white adipose tissue inflammation and changes in adipose tissue and ectopic fat depots.

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Journal:  Surg Endosc       Date:  2013-10-03       Impact factor: 4.584

4.  Insulin-lowering effects of metformin in women with early breast cancer.

Authors:  Pamela J Goodwin; Kathleen I Pritchard; Marguerite Ennis; Mark Clemons; Margaret Graham; I George Fantus
Journal:  Clin Breast Cancer       Date:  2008-12       Impact factor: 3.225

Review 5.  Weight control and physical activity in cancer prevention: international evaluation of the evidence.

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6.  Pancreatic ductal adenocarcinoma: is there a survival difference for R1 resections versus locally advanced unresectable tumors? What is a "true" R0 resection?

Authors:  Ioannis T Konstantinidis; Andrew L Warshaw; Jill N Allen; Lawrence S Blaszkowsky; Carlos Fernandez-Del Castillo; Vikram Deshpande; Theodore S Hong; Eunice L Kwak; Gregory Y Lauwers; David P Ryan; Jennifer A Wargo; Keith D Lillemoe; Cristina R Ferrone
Journal:  Ann Surg       Date:  2013-04       Impact factor: 12.969

Review 7.  Pancreatic surgery.

Authors:  Timothy R Donahue; Howard A Reber
Journal:  Curr Opin Gastroenterol       Date:  2013-09       Impact factor: 3.287

8.  Richness of human gut microbiome correlates with metabolic markers.

Authors:  Emmanuelle Le Chatelier; Trine Nielsen; Junjie Qin; Edi Prifti; Falk Hildebrand; Gwen Falony; Mathieu Almeida; Manimozhiyan Arumugam; Jean-Michel Batto; Sean Kennedy; Pierre Leonard; Junhua Li; Kristoffer Burgdorf; Niels Grarup; Torben Jørgensen; Ivan Brandslund; Henrik Bjørn Nielsen; Agnieszka S Juncker; Marcelo Bertalan; Florence Levenez; Nicolas Pons; Simon Rasmussen; Shinichi Sunagawa; Julien Tap; Sebastian Tims; Erwin G Zoetendal; Søren Brunak; Karine Clément; Joël Doré; Michiel Kleerebezem; Karsten Kristiansen; Pierre Renault; Thomas Sicheritz-Ponten; Willem M de Vos; Jean-Daniel Zucker; Jeroen Raes; Torben Hansen; Peer Bork; Jun Wang; S Dusko Ehrlich; Oluf Pedersen
Journal:  Nature       Date:  2013-08-29       Impact factor: 49.962

9.  The role of chronic inflammation in obesity-associated cancers.

Authors:  Maria E Ramos-Nino
Journal:  ISRN Oncol       Date:  2013-05-30

10.  Calorie restriction decreases murine and human pancreatic tumor cell growth, nuclear factor-κB activation, and inflammation-related gene expression in an insulin-like growth factor-1-dependent manner.

Authors:  Alison E Harvey; Laura M Lashinger; Drew Hays; Lauren M Harrison; Kimberly Lewis; Susan M Fischer; Stephen D Hursting
Journal:  PLoS One       Date:  2014-05-07       Impact factor: 3.240
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  18 in total

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Authors:  Kinji Asahina; Steven Balog; Edward Hwang; Eugene Moon; Emily Wan; Kaitlin Skrypek; Yibu Chen; Jay Fernandez; Janet Romo; Qihong Yang; Keane Lai; Samuel W French; Hidekazu Tsukamoto
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2019-11-25       Impact factor: 4.052

Review 2.  Gender Differences in Obesity-Related Cancers.

Authors:  Georgia Argyrakopoulou; Maria Dalamaga; Nikolaos Spyrou; Alexander Kokkinos
Journal:  Curr Obes Rep       Date:  2021-02-01

3.  Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma.

Authors:  Katherine Minjee Chung; Jaffarguriqbal Singh; Lauren Lawres; Kimberly Judith Dorans; Cathy Garcia; Daniel B Burkhardt; Rebecca Robbins; Arjun Bhutkar; Rebecca Cardone; Xiaojian Zhao; Ana Babic; Sara A Vayrynen; Andressa Dias Costa; Jonathan A Nowak; Daniel T Chang; Richard F Dunne; Aram F Hezel; Albert C Koong; Joshua J Wilhelm; Melena D Bellin; Vibe Nylander; Anna L Gloyn; Mark I McCarthy; Richard G Kibbey; Smita Krishnaswamy; Brian M Wolpin; Tyler Jacks; Charles S Fuchs; Mandar Deepak Muzumdar
Journal:  Cell       Date:  2020-04-17       Impact factor: 41.582

4.  Risk of pancreatic cancer in patients with systemic lupus erythematosus: a meta-analysis.

Authors:  Min-Seok Seo; Jina Yeo; In Cheol Hwang; Jae-Yong Shim
Journal:  Clin Rheumatol       Date:  2019-07-03       Impact factor: 2.980

5.  KRAS Controls Pancreatic Cancer Cell Lipid Metabolism and Invasive Potential through the Lipase HSL.

Authors:  Cody N Rozeveld; Katherine M Johnson; Lizhi Zhang; Gina L Razidlo
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6.  Transcriptome Analysis of Subcutaneous Adipose Tissue from Severely Obese Patients Highlights Deregulation Profiles in Coding and Non-Coding Oncogenes.

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Journal:  Int J Mol Sci       Date:  2021-02-17       Impact factor: 5.923

Review 7.  Models of pancreatic ductal adenocarcinoma.

Authors:  Rayane Dennaoui; Hridaya Shrestha; Kay-Uwe Wagner
Journal:  Cancer Metastasis Rev       Date:  2021-09-07       Impact factor: 9.264

Review 8.  Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development.

Authors:  Enrique Rozengurt; Guido Eibl
Journal:  World J Gastroenterol       Date:  2019-04-21       Impact factor: 5.742

9.  LncRNA HOTTIP Participates in Cisplatin Resistance of Tumor Cells by Regulating miR-137 Expression in Pancreatic Cancer.

Authors:  Feng Yin; Qian Zhang; Zhihui Dong; Jie Hu; Zhiqiang Ma
Journal:  Onco Targets Ther       Date:  2020-04-01       Impact factor: 4.147

Review 10.  Fatty Acids and Membrane Lipidomics in Oncology: A Cross-Road of Nutritional, Signaling and Metabolic Pathways.

Authors:  Carla Ferreri; Anna Sansone; Rosaria Ferreri; Javier Amézaga; Itziar Tueros
Journal:  Metabolites       Date:  2020-08-25
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