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Literature DB >> 29339396

Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model.

Anthony D Kang^1,2, Kenneth P Smith¹, Anders H Berg¹, Katherine A Truelson^1,3, George M Eliopoulos⁴, Christopher McCoy⁵, James E Kirby⁶.

Abstract

Apramycin, an aminocyclitol aminoglycoside, was rapidly bactericidal against Acinetobacter baumannii In a neutropenic murine thigh infection model, treatment-associated A. baumannii CFU reductions of >4 log10 per thigh were observed for all exposures for which area under the curve (AUC)/MIC ratio was >50 and maximum concentration of drug in serum (Cmax)/MIC was ≈10 or higher. Based on these findings, we suggest that apramycin deserves further preclinical exploration as a repurposed therapeutic for multidrug-resistant Gram-negative pathogens, including A. baumannii.

Entities: Chemical Disease Species

Keywords: antimicrobial; apramycin; maximum tolerated dose; mouse thigh model; pharmacodynamics; pharmacokinetics; resistance; time-kill

Mesh：

Substances：

Year: 2018 PMID： 29339396 PMCID： PMC5913965 DOI： 10.1128/AAC.02585-17

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

29 in total

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4. Widespread occurrence of aminoglycoside resistance due to ArmA methylase in imipenem-resistant Acinetobacter baumannii isolates in China.

Authors: Yun-song Yu; Hua Zhou; Qing Yang; Ya-gang Chen; Lan-juan Li
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5. Emergence of Klebsiella pneumoniae co-producing NDM-1, OXA-48, CTX-M-15, CMY-16, QnrA and ArmA in Switzerland.

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6. Evaluation of apramycin activity against carbapenem-resistant and -susceptible strains of Enterobacteriaceae.

Authors: Kenneth P Smith; James E Kirby
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7. The association of aminoglycoside plasma levels with mortality in patients with gram-negative bacteremia.

Authors: R D Moore; C R Smith; P S Lietman
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8. Effects of apramycin, a novel aminoglycoside antibiotic on bacterial protein synthesis.

Authors: S Perzynski; M Cannon; E Cundliffe; S B Chahwala; J Davies
Journal: Eur J Biochem Date: 1979-09

9. Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides.

Authors: Jun-ichi Wachino; Keigo Shibayama; Hiroshi Kurokawa; Kouji Kimura; Kunikazu Yamane; Satowa Suzuki; Naohiro Shibata; Yasuyoshi Ike; Yoshichika Arakawa
Journal: Antimicrob Agents Chemother Date: 2007-09-17 Impact factor: 5.191

10. Aminoglycoside resistance 16S rRNA methyltransferases block endogenous methylation, affect translation efficiency and fitness of the host.

Authors: Virginia S Lioy; Sylvie Goussard; Vincent Guerineau; Eun-Jeong Yoon; Patrice Courvalin; Marc Galimand; Catherine Grillot-Courvalin
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12 in total

Review 1. New Treatment Options against Carbapenem-Resistant Acinetobacter baumannii Infections.

Authors: Burcu Isler; Yohei Doi; Robert A Bonomo; David L Paterson
Journal: Antimicrob Agents Chemother Date: 2018-12-21 Impact factor: 5.191

2. Evaluation of apramycin against spectinomycin-resistant and -susceptible strains of Neisseria gonorrhoeae.

Authors: Stefan Riedel; Divya Vijayakumar; Gretchen Berg; Anthony D Kang; Kenneth P Smith; James E Kirby
Journal: J Antimicrob Chemother Date: 2019-05-01 Impact factor: 5.790

3. Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant.

Authors: Jonathan C K Quirke; Parasuraman Rajasekaran; Vikram A Sarpe; Amr Sonousi; Ivan Osinnii; Marina Gysin; Klara Haldimann; Qiao-Jun Fang; Dimitri Shcherbakov; Sven N Hobbie; Su-Hua Sha; Jochen Schacht; Andrea Vasella; Erik C Böttger; David Crich
Journal: J Am Chem Soc Date: 2019-12-17 Impact factor: 15.419

4. Evaluation of apramycin activity against methicillin-resistant, methicillin-sensitive, and vancomycin-intermediate Staphylococcus aureus clinical isolates.

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Review 10. New strategies and structural considerations in development of therapeutics for carbapenem-resistant Enterobacteriaceae.

Authors: Thea Brennan-Krohn; Roman Manetsch; George A O'Doherty; James E Kirby
Journal: Transl Res Date: 2020-03-02 Impact factor: 7.012