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Literature DB >> 29934071

Evaluation of apramycin activity against methicillin-resistant, methicillin-sensitive, and vancomycin-intermediate Staphylococcus aureus clinical isolates.

Katherine A Truelson¹, Thea Brennan-Krohn², Kenneth P Smith², James E Kirby³.

Abstract

We evaluated the in vitro activity of apramycin against clinical strains of vancomycin-intermediate and methicillin-resistant and -susceptible Staphylococcus aureus. Apramycin demonstrated an MIC50/MIC90 of 8/16 μg/mL. No strains had an MIC above the epidemiological cutoff value of 32 μg/mL, suggesting apramycin resistance mechanisms are rare in this strain population. The mounting evidence for broad-spectrum in vitro activity of apramycin against S. aureus and other bacterial species suggests that further exploration of apramycin or derivatives as repurposed human therapeutics is warranted.

Entities: Chemical Disease Gene Species

Keywords: Activity spectrum; Aminoglycoside; Antibiotic; Apramycin; Gentamicin; Natural product; Repurposing; Staphylococcus aureus; Synergy

Mesh：

Substances：

Year: 2018 PMID： 29934071 PMCID： PMC6131043 DOI： 10.1016/j.diagmicrobio.2018.05.018

Source DB: PubMed Journal: Diagn Microbiol Infect Dis ISSN： 0732-8893 Impact factor: 2.803

37 in total

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