Joanne M George1, Simona Fiori2, Jurgen Fripp3, Kerstin Pannek3, Andrea Guzzetta2, Michael David4, Robert S Ware5, Stephen E Rose3, Paul B Colditz6, Roslyn N Boyd7. 1. Queensland Cerebral Palsy and Rehabilitation Research Centre, Centre for Children's Health Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia. Electronic address: j.george2@uq.edu.au. 2. Stella Maris Scientific Institute, Department of Developmental Neuroscience, The University of Pisa, Pisa, Italy. 3. Health and Biosecurity, The Australian e-Health Research Centre, CSIRO, Brisbane, Australia. 4. School of Population Health, The University of Queensland, Brisbane, Australia; School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, Australia. 5. Menzies Health Institute Queensland, Griffith University, Brisbane, Australia; Queensland Centre for Intellectual and Developmental Disability, The University of Queensland, Brisbane, Australia. 6. University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, Australia; Perinatal Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Australia. 7. Queensland Cerebral Palsy and Rehabilitation Research Centre, Centre for Children's Health Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia.
Abstract
AIM: This study aimed to examine associations between structural MRI and concurrent motor, neurological and neurobehavioral measures at 30-32 weeks postmenstrual age (PMA; 'Early'), and at term equivalent age ('Term'). METHOD: In this prospective cohort study, infants underwent Early MRI (n = 119; 73 male; median 32 weeks 1 day PMA) and Term MRI (n = 102; 61 male; median 40 weeks 4 days PMA) at 3 T. Structural images were scored generating white matter (WM), cortical gray matter, deep gray matter, cerebellar and global brain abnormality scores. Clinical measures were General Movements Assessment (GMs), Hammersmith Neonatal Neurological Examination (HNNE) and NICU Neonatal Neurobehavioral Scale (NNNS). The Premie-Neuro was administered Early and the Test of Infant Motor Performance (TIMP) and a visual assessment at Term. RESULTS: Early MRI cerebellar scores were strongly associated with neurological components of HNNE (reflexes), NNNS (Hypertonicity), the Premie-Neuro neurological subscale (regression coefficient β = -0.06; 95% confidence interval CI = -0.09, -0.04; p < .001) and cramped-synchronized GMs (β = 1.10; 95%CI = 0.57, 1.63; p < .001). Term MRI WM and global scores were strongly associated with the TIMP (WM β = -1.02; 95%CI = -1.67, -0.36; p = .002; global β = -1.59; 95%CI = -2.62, -0.56; p = .001). INTERPRETATION: Brain structure on Early and Term MRI was associated with concurrent motor, neurological and neurobehavioral function in very preterm infants. Crown
AIM: This study aimed to examine associations between structural MRI and concurrent motor, neurological and neurobehavioral measures at 30-32 weeks postmenstrual age (PMA; 'Early'), and at term equivalent age ('Term'). METHOD: In this prospective cohort study, infants underwent Early MRI (n = 119; 73 male; median 32 weeks 1 day PMA) and Term MRI (n = 102; 61 male; median 40 weeks 4 days PMA) at 3 T. Structural images were scored generating white matter (WM), cortical gray matter, deep gray matter, cerebellar and global brain abnormality scores. Clinical measures were General Movements Assessment (GMs), Hammersmith Neonatal Neurological Examination (HNNE) and NICU Neonatal Neurobehavioral Scale (NNNS). The Premie-Neuro was administered Early and the Test of Infant Motor Performance (TIMP) and a visual assessment at Term. RESULTS: Early MRI cerebellar scores were strongly associated with neurological components of HNNE (reflexes), NNNS (Hypertonicity), the Premie-Neuro neurological subscale (regression coefficient β = -0.06; 95% confidence interval CI = -0.09, -0.04; p < .001) and cramped-synchronized GMs (β = 1.10; 95%CI = 0.57, 1.63; p < .001). Term MRI WM and global scores were strongly associated with the TIMP (WM β = -1.02; 95%CI = -1.67, -0.36; p = .002; global β = -1.59; 95%CI = -2.62, -0.56; p = .001). INTERPRETATION: Brain structure on Early and Term MRI was associated with concurrent motor, neurological and neurobehavioral function in very preterm infants. Crown
Authors: L van Eijk; M Seidel; K Pannek; J M George; S Fiori; A Guzzetta; A Coulthard; J Bursle; R S Ware; D Bradford; S Rose; P B Colditz; R N Boyd; J Fripp Journal: AJNR Am J Neuroradiol Date: 2021-08-19 Impact factor: 4.966
Authors: Joanne M George; Alex M Pagnozzi; Samudragupta Bora; Roslyn N Boyd; Paul B Colditz; Stephen E Rose; Robert S Ware; Kerstin Pannek; Jane E Bursle; Jurgen Fripp; Karen Barlow; Kartik Iyer; Shaneen J Leishman; Rebecca L Jendra Journal: BMJ Open Date: 2020-05-12 Impact factor: 2.692
Authors: Kristen L Benninger; Terrie E Inder; Amy M Goodman; C Michael Cotten; Douglas R Nordli; Tushar A Shah; James C Slaughter; Nathalie L Maitre Journal: Pediatr Res Date: 2020-03-27 Impact factor: 3.756