| Literature DB >> 29338219 |
Xudong Shi1, Kai Gao1, Hao Huang1, Ran Gao1.
Abstract
Pretargeted immuno-PET imaging based on the bioorthogonal chemistry between 18F-labeled Reppe anhydride derivatives and tetrazine conjugates of the EGFR-specific monoclonal antibodies cetuximab and panitumumab was performed. This pretargeting approach yielded high target-to-nontarget ratios. Furthermore, due to the fast clearance rate of the PET probe, the overall radiation burden to nontarget tissues was also substantially decreased.Entities:
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Year: 2018 PMID: 29338219 DOI: 10.1021/acs.bioconjchem.8b00023
Source DB: PubMed Journal: Bioconjug Chem ISSN: 1043-1802 Impact factor: 4.774