Literature DB >> 2933471

Alterations in the immune response of nonresponders to the hepatitis B vaccine.

M J Nowicki, M J Tong, R E Bohman.   

Abstract

The phenotypic characteristics of peripheral blood lymphocytes (PBLs) from responders and nonresponders to hepatitis B (HB) vaccine and their response to pokeweed mitogen (PWM) stimulation in vitro were compared. The nonresponders had significantly higher absolute numbers and percentages of T11+, HNK-1+, and T8+ lymphocytes. Also, after PWM stimulation, PBLs from HB-vaccine nonresponders had impaired IgG and IgM production and failed to produce antibodies to HB surface antigen in vitro. These findings suggest that healthy individuals who fail to produce such antibodies have a higher population of suppressor lymphocytes that alters their normal immune response to HB vaccination.

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Year:  1985        PMID： 2933471     DOI： 10.1093/infdis/152.6.1245

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  13 in total

1.  Response to HBV vaccination in patients with severe liver disease. Absence of an HLA effect.

Authors:  D H Van Thiel; J S Gavaler
Journal:  Dig Dis Sci       Date:  1992-09       Impact factor: 3.199

2.  The cellular basis for lack of antibody response to hepatitis B vaccine in humans.

Authors:  E Egea; A Iglesias; M Salazar; C Morimoto; M S Kruskall; Z Awdeh; S F Schlossman; C A Alper; E J Yunis
Journal:  J Exp Med       Date:  1991-03-01       Impact factor: 14.307

3.  Effects of mitogens and lymphokines on the regulation of the immune response to HBs antigen in vitro.

Authors:  I Knöller; U J Hoffmann; H H Werchau; W König
Journal:  Immunology       Date:  1990-11       Impact factor: 7.397

4.  The spot-ELISA: a sensitive in vitro method to study the immune response to hepatitis B surface antigen.

Authors:  P J Wismans; J van Hattum; G C De Gast; H J Endeman; J Poel; B Stolk; T Maikoe; G C Mudde
Journal:  Clin Exp Immunol       Date:  1989-10       Impact factor: 4.330

5.  Immunogenicity of plasma-derived hepatitis B vaccine: relationship to site of injection and obesity.

Authors:  S M Lemon; D J Weber
Journal:  J Gen Intern Med       Date:  1986 May-Jun       Impact factor: 5.128

6.  Hepatitis B vaccination: effect of re-vaccination and injection site in suboptimal responders.

Authors:  P J Pead; A A Saeed
Journal:  Eur J Epidemiol       Date:  1986-09       Impact factor: 8.082

7.  Induction of the in vitro anti-HBs response by hepatitis B surface antigen.

Authors:  L G Filion; R Saginur
Journal:  Clin Exp Immunol       Date:  1988-12       Impact factor: 4.330

8.  Enumeration of hepatitis B surface antigen-specific B lymphocytes in responder and non-responder normal individuals vaccinated with recombinant hepatitis B surface antigen.

Authors:  M A Shokrgozar; F Shokri
Journal:  Immunology       Date:  2001-09       Impact factor: 7.397

Review 9.  Use of licensed vaccines for active immunization of the immunocompromised host.

Authors:  L A Pirofski; A Casadevall
Journal:  Clin Microbiol Rev       Date:  1998-01       Impact factor: 26.132

10.  Influence of vaccination schedules and host factors on antibody response following hepatitis B vaccination.

Authors:  G Hess; V Hingst; J Cseke; H L Bock; R Clemens
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1992-04       Impact factor: 3.267
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