Praveen Kilaru1, Sunil P Acharya, Pinjing Zhao. 1. Department of Chemistry and Biochemistry, North Dakota State University, Fargo, ND 58108-6050, USA. pinjing.zhao@ndsu.edu.
Abstract
We report a new catalyst design for N-heterocycle synthesis that utilizes an alkene-tethered amide moiety as a directing group for aromatic C-H activation. This tethering directing group strategy is demonstrated in a ruthenium-catalyzed intramolecular alkene hydroarylation with N-aryl acrylamides to form oxindole products.
We report a new catalyst design for N-heterocycle synthesis that utilizes ann class="Chemical">alkene-tethered amide moiety as a directing group for aromatic C-H activation. This tethering directing group strategy is demonstrated in a ruthenium-catalyzed intramolecular alkene hydroarylation with N-aryl acrylamides to form oxindole products.