Literature DB >> 29317180

Oral administration of fisetin promotes the induction of hippocampal long-term potentiation in vivo.

Wen-Bin He1, Kazuho Abe1, Tatsuhiro Akaishi2.   

Abstract

To explore memory enhancing effect of the flavonoid fisetin, we investigated the effect of oral administration of flavonoids on the induction of long-term potentiation (LTP) at hippocampal CA1 synapses of anesthetized rats. Among four flavonoids (fisetin, quercetin, luteolin and myricetin) tested, only fisetin significantly facilitated the induction of hippocampal LTP. The effect of oral fisetin was abolished by intracerebroventricular injection of U0126, an agent that was previously found to inhibit its effect in hippocampal slices in vitro. These results suggest that orally administered fisetin crosses the blood-brain barrier and promotes synaptic functions in the hippocampus.
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Entities:  

Keywords:  Fisetin; Hippocampal long-term potentiation; Oral administration

Mesh：

Substances：

Year:  2017        PMID： 29317180     DOI： 10.1016/j.jphs.2017.12.008

Source DB:  PubMed          Journal:  J Pharmacol Sci        ISSN： 1347-8613            Impact factor:   3.337


  9 in total

1.  Fisetin decreases the duration of ictal-like discharges in mouse hippocampal slices.

Authors:  Hilal Ozturk; Harun Basoglu; Nuri Yorulmaz; Selcen Aydin-Abidin; Ismail Abidin
Journal:  J Biol Phys       Date:  2022-08-10       Impact factor: 1.560

2.  Fisetin inhibits tau aggregation by interacting with the protein and preventing the formation of β-strands.

Authors:  Shifeng Xiao; Yafei Lu; Qiuping Wu; Jiaying Yang; Jierui Chen; Suyue Zhong; David Eliezer; Qiulong Tan; Chengchen Wu
Journal:  Int J Biol Macromol       Date:  2021-03-01       Impact factor: 8.025

Review 3.  Preventing and Treating Neurological Disorders with the Flavonol Fisetin.

Authors:  Pamela Maher
Journal:  Brain Plast       Date:  2021-02-09

4.  Fisetin ameliorates cognitive impairment by activating mitophagy and suppressing neuroinflammation in rats with sepsis-associated encephalopathy.

Authors:  Hongguang Ding; Ya Li; Shenglong Chen; Yin Wen; Shiying Zhang; Ensi Luo; Xusheng Li; Wenhong Zhong; Hongke Zeng
Journal:  CNS Neurosci Ther       Date:  2021-11-27       Impact factor: 5.243

5.  Accumulation of Senescent Neural Cells in Murine Lupus With Depression-Like Behavior.

Authors:  Yuki Saito; Maki Miyajima; Sena Yamamoto; Tsukasa Sato; Norihiro Miura; Mineko Fujimiya; Takako S Chikenji
Journal:  Front Immunol       Date:  2021-11-03       Impact factor: 7.561

6.  Extracellular signal-regulated kinase-dependent phosphorylation of histone H3 serine 10 is involved in the pathogenesis of traumatic brain injury.

Authors:  Yu Zhang; Xin Yang; Xinran Hou; Wen Zhou; Changlong Bi; Zhuanyi Yang; Sining Lu; Zijin Ding; Zhuofeng Ding; Yu Zou; Qulian Guo; Michael K E Schäfer; Changsheng Huang
Journal:  Front Mol Neurosci       Date:  2022-09-29       Impact factor: 6.261

7.  Fisetin Prevents HT22 Cells From High Glucose-Induced Neurotoxicity via PI3K/Akt/CREB Signaling Pathway.

Authors:  Shenshen Zhang; Ran Xue; Yaping Geng; Hao Wang; Wenjie Li
Journal:  Front Neurosci       Date:  2020-03-19       Impact factor: 4.677

8.  GSK-3β-Targeting Fisetin Promotes Melanogenesis in B16F10 Melanoma Cells and Zebrafish Larvae through β-Catenin Activation.

Authors:  Ilandarage Menu Neelaka Molagoda; Wisurumuni Arachchilage Hasitha Maduranga Karunarathne; Sang Rul Park; Yung Hyun Choi; Eui Kyun Park; Cheng-Yun Jin; Haiyang Yu; Wol Soon Jo; Kyoung Tae Lee; Gi-Young Kim
Journal:  Int J Mol Sci       Date:  2020-01-02       Impact factor: 5.923

Review 9.  Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases.

Authors:  Pamela Maher; Antonio Currais; David Schubert
Journal:  Cell Chem Biol       Date:  2020-11-10       Impact factor: 8.116
  9 in total

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