Literature DB >> 29312763

NUT midline carcinoma as a primary lung tumor: a case report.

Jiashun Cao1, Donghong Chen1, Fan Yang1, Jingjing Yao2, Weipeng Zhu1, Chuanduo Zhao1.   

Abstract

NUT (nuclear protein in testis) midline carcinoma is a rare malignant tumor arising in midline structures, such as head, neck and mediastinum. In the 2015 WHO classification of lung tumours, it was categorized in "Epithelial tumors". However, because of limited clinical data, its biological features have not been fully recognized. We report a case of NUT midline carcinoma presented as a primary lung tumor. Pneumonectomy was performed without any neoadjuvant therapy and it turned out to be a gross total resection. Even so, the prognosis is poor with a disease-free survival of 2 months and an overall survival of 6 months.

Entities:  

Keywords:  NUT midline carcinoma; lung tumor; pneumonectomy

Year:  2017        PMID： 29312763      PMCID： PMC5756942          DOI： 10.21037/jtd.2017.11.50

Source DB:  PubMed          Journal:  J Thorac Dis        ISSN： 2072-1439            Impact factor:   2.895


  21 in total

1.  The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification.

Authors:  William D Travis; Elisabeth Brambilla; Andrew G Nicholson; Yasushi Yatabe; John H M Austin; Mary Beth Beasley; Lucian R Chirieac; Sanja Dacic; Edwina Duhig; Douglas B Flieder; Kim Geisinger; Fred R Hirsch; Yuichi Ishikawa; Keith M Kerr; Masayuki Noguchi; Giuseppe Pelosi; Charles A Powell; Ming Sound Tsao; Ignacio Wistuba
Journal:  J Thorac Oncol       Date:  2015-09       Impact factor: 15.609

2.  A case of endobronchial NUT midline carcinoma with intraluminal growth.

Authors:  Sho Watanabe; Satoshi Hirano; Sohtaro Mine; Akihiko Yoshida; Toru Motoi; Satoshi Ishii; Go Naka; Yuichiro Takeda; Toru Igari; Haruhito Sugiyama; Nobuyuki Kobayashi
Journal:  Anticancer Res       Date:  2015-03       Impact factor: 2.480

Review 3.  A review of NUT midline carcinoma.

Authors:  Edward B Stelow
Journal:  Head Neck Pathol       Date:  2011-01-08

4.  Upper respiratory tract carcinoma with chromosomal translocation 15;19: evidence for a distinct disease entity of young patients with a rapidly fatal course.

Authors:  S O Vargas; C A French; P N Faul; J A Fletcher; I J Davis; P Dal Cin; A R Perez-Atayde
Journal:  Cancer       Date:  2001-09-01       Impact factor: 6.860

5.  Novel t(15;19)(q15;p13) chromosome abnormality in a thymic carcinoma.

Authors:  I Kubonishi; N Takehara; J Iwata; H Sonobe; Y Ohtsuki; T Abe; I Miyoshi
Journal:  Cancer Res       Date:  1991-06-15       Impact factor: 12.701

6.  Midline carcinoma of children and young adults with NUT rearrangement.

Authors:  Christopher A French; Jeffery L Kutok; William C Faquin; Jeffrey A Toretsky; Cristina R Antonescu; Constance A Griffin; Vania Nose; Sara O Vargas; Mary Moschovi; Fotini Tzortzatou-Stathopoulou; Isao Miyoshi; Antonio R Perez-Atayde; Jon C Aster; Jonathan A Fletcher
Journal:  J Clin Oncol       Date:  2004-10-15       Impact factor: 44.544

7.  Intrathoracic carcinoma in an 11-year-old girl showing a translocation t(15;19).

Authors:  U R Kees; M T Mulcahy; M L Willoughby
Journal:  Am J Pediatr Hematol Oncol       Date:  1991

8.  MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma.

Authors:  Adlai R Grayson; Erica M Walsh; Michael J Cameron; Jernej Godec; Todd Ashworth; Jessica M Ambrose; Alexandra B Aserlind; Hongfang Wang; Gerard Evan; Michael J Kluk; James E Bradner; Jon C Aster; Christopher A French
Journal:  Oncogene       Date:  2013-04-22       Impact factor: 9.867

9.  Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody.

Authors:  Herbert Haack; Laura A Johnson; Christopher J Fry; Katherine Crosby; Roberto D Polakiewicz; Edward B Stelow; Seung-Mo Hong; Brian E Schwartz; Michael J Cameron; Mark A Rubin; Martin C Chang; Jon C Aster; Christopher A French
Journal:  Am J Surg Pathol       Date:  2009-07       Impact factor: 6.394

10.  BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.

Authors:  C A French; C L Ramirez; J Kolmakova; T T Hickman; M J Cameron; M E Thyne; J L Kutok; J A Toretsky; A K Tadavarthy; U R Kees; J A Fletcher; J C Aster
Journal:  Oncogene       Date:  2007-10-15       Impact factor: 9.867
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  5 in total

Review 1.  A 47-year-old woman with nuclear protein in testis midline carcinoma masquerading as a sinus infection: a case report and review of the literature.

Authors:  Safwan K Elkhatib; Beth K Neilsen; Richard L Sleightholm; Michael J Baine; Weining Zhen
Journal:  J Med Case Rep       Date:  2019-03-11

2.  NUT midline carcinoma in a young pregnant female: a case report.

Authors:  Sebastian Joel; Friederike Weschenfelder; Ekkehard Schleussner; Gunther O Hofmann; Wolfram Weschenfelder
Journal:  World J Surg Oncol       Date:  2020-11-07       Impact factor: 2.754

3.  [A Case Report of Primary Pulmonary NUT Carcinoma and Literature Review].

Authors:  Xiaoqin Liu; Yanying Li; Min Yu; Lin Zhou
Journal:  Zhongguo Fei Ai Za Zhi       Date:  2021-01-20

4.  NUT Carcinoma of the Lung：A Case report and Literature Analysis.

Authors:  Rongshuang Zhao; Ze Hua; Xiaodong Hu; Qi Zhang; Jin Zhang; Jian Wang
Journal:  Front Oncol       Date:  2022-07-12       Impact factor: 5.738

Review 5.  Nuclear protein of the testis midline carcinoma of the thorax.

Authors:  Ayae Saiki; Keita Sakamoto; Yuan Bee; Takehiro Izumo
Journal:  Jpn J Clin Oncol       Date:  2022-05-31       Impact factor: 2.925
  5 in total

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