| Literature DB >> 29310319 |
Shan-Wen Hu1, Shu Qiao1, Jian-Bin Pan1, Bin Kang2, Jing-Juan Xu3, Hong-Yuan Chen1.
Abstract
A paper-based SERS test strip combining strengths of paper chip and Raman active substrate was demonstrated to overcome challenges in spectroscopic sensing of complicated samples and realize quantitative detection of disease markers in whole blood. The precisely controlled Au NPs were not only capable of generating condensed hot spots on the fibers, but also enhanced the size exclusion effect of paper, resulting in the novel performance on both SERS detection and sample pretreatment. A biosensor for Mucin-1 is developed by equipping the Au NPs with aptamer. Combining all these merits, this small, cheap and portable test strip might find wide application in clinical diagnosis and health evaluation.Entities:
Keywords: Au NPs; Mucin-1; Paper-based test strip; SERS; Whole blood
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Year: 2017 PMID： 29310319 DOI： 10.1016/j.talanta.2017.10.038
Source DB: PubMed Journal: Talanta ISSN： 0039-9140 Impact factor: 6.057